Oncotarget

Research Papers:

Systematic analysis of gene expression alterations and clinical outcomes of STAT3 in cancer

Xiangrong Cui, Xuan Jing, Qin Yi, Chunlan Long, Bin Tan, Xin Li, Xueni Chen, Yue Huang, Zhongping Xiang, Jie Tian and Jing Zhu _

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Oncotarget. 2018; 9:3198-3213. https://doi.org/10.18632/oncotarget.23226

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Abstract

Xiangrong Cui1,2,3,*, Xuan Jing5,*, Qin Yi1,2,3, Chunlan Long1,2,3, Bin Tan1,2,3, Xin Li1,2,3, Xueni Chen1,2,3, Yue Huang1,2,3, Zhongping Xiang1,2,3, Jie Tian4 and Jing Zhu1,2,3

1Pediatric Research Institute, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China

2China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China

3Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China

4Cardiovascular Department (Internal Medicine), Children’s Hospital of Chongqing Medical University, Chongqing 400014, China

5Clinical laboratory, Shanxi Province people’s hospital, Shanxi 030000, Taiyuan, China

*These authors contributed equally to this work

Correspondence to:

Jing Zhu, email: 412232858@qq.com

Keywords: STAT3; overall survival; mutation; copy number alteration

Received: August 14, 2017     Accepted: November 16, 2017     Published: December 14, 2017

ABSTRACT

Accumulated studies have provided controversial evidences of prognostic value for signal transducer and activator of transcription proteins 3 (STAT3) in cancers. To address this inconsistency, we performed a systematic analysis to determine whether STAT3 can serve as a prognostic marker in human cancers. STAT3 expression was assessed using Oncomine analysis. cBioPortal, Kaplan-Meier Plotter, and Prognoscan were performed to identify the prognostic roles of STAT3 in human cancers. The copy number alteration, mutation, interactive analysis, and visualize the altered networks were performed by cBioPortal. We found that STAT3 was more frequently overexpressed in lung, ovarian, gastric, blood and brain cancers than their normal tissues and its expression might be negatively related with the prognosis. In addition, STAT3 mutation mainly occurred in uterine cancer and existed in a hotspot in SH2 domain. Those findings suggest that STAT3 might serve as a diagnostic and therapeutic target for certain types of cancer, such as lung, ovarian, gastric, blood and brain cancers. However, future research is required to validate our findings and thus promote the clinical utility of STAT3 in those cancers prognosis evaluation.


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