NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma

Bo-Hua Su; Jing Qu; Min Song; Xiao-Yu Huang; Xiao-Meng Hu; Jian Xie; Yong Zhao; Lin-Can Ding; Lin She; Jiang Chen; Li-Song Lin; Xu Lin; Da-Li Zheng; You-Guang Lu

doi:10.18632/oncotarget.2321

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma

Bo-Hua Su, Jing Qu, Min Song, Xiao-Yu Huang, Xiao-Meng Hu, Jian Xie, Yong Zhao, Lin-Can Ding, Lin She, Jiang Chen, Li-Song Lin, Xu Lin, Da-Li Zheng _ and You-Guang Lu

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2014; 5:6885-6895. https://doi.org/10.18632/oncotarget.2321

Metrics: PDF 2274 views | HTML 2951 views | ?

Abstract

Bo-Hua Su1,*, Jing Qu1,*, Min Song1,*, Xiao-Yu Huang1, Xiao-Meng Hu1, Jian Xie1, Yong Zhao2, Lin-Can Ding1, Lin She1, Jiang Chen3, Li-Song Lin4, Xu Lin5, Da-Li Zheng5,6 and You-Guang Lu1

1 Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China

2 Department of Pathology, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China

3 Center of Dental Implant, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China

4 Department of Oral and Maxillofacial Surgery, Affiliated First Hospital of Fujian Medical University, Fuzhou, China

5 Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China

6 Molecular Oncology, Moffitt Cancer Center, Tampa, FL, United States

* These authors contributed equally to this work

Correspondence:

Da-Li Zheng, email:

You-Guang Lu, email:

Keywords: NOTCH1, salivary adenoid cystic carcinoma, proliferation, apoptosis, metastasis

Received: July 07, 2014 Accepted: August 05, 2014 Published: August 06, 2014

Abstract

Background: Numerous studies have reported both the tumor-suppressive and oncogenic roles of the Notch pathway, indicating that Notch activity regulates tumor biology in a complex, context-dependent manner. The aim of the present study was to identify the role of NOTCH1 in the cell growth and metastasis of SACC.

Methods: We analyzed the expression of NOTCH1 in clinical SACC samples using immunohistochemical staining. We silenced the expression of NOTCH1 and overexpressed activated NOTCH1 to elucidate the effects of NOTCH1 on proliferation, migration and invasion. NOTCH1 target genes were validated by real-time PCR.

Results: Our results showed that NOTCH1 was upregulated in SACC tissues when compared with normal tissues, and this upregulation was further enhanced in SACC tissues with metastasis and recurrence when compared with SACC tissues without metastasis. Overexpression of NOTCH1 in SACC cells promoted cell growth, migration and invasion, and knockdown of NOTCH1 inhibited cell proliferation in vitro and tumorigenicity in vivo by inducing cell apoptosis.

Conclusions:The results of this study suggest that NOTCH1 plays a key role in the cell growth, anti-apoptosis, and metastasis of SACC. NOTCH1 inhibitors might therefore have potential therapeutic applications in treating SACC patients by inhibiting cancer cell growth and metastasis.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 2321

Publication Alerts

Research Papers:

NOTCH1 signaling contributes to cell growth, anti-apoptosis and metastasis in salivary adenoid cystic carcinoma

Abstract