Oncotarget

Reviews:

Inflammatory responses and inflammation-associated diseases in organs

Linlin Chen, Huidan Deng, Hengmin Cui _, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang and Ling Zhao

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Oncotarget. 2018; 9:7204-7218. https://doi.org/10.18632/oncotarget.23208

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Abstract

Linlin Chen1,*, Huidan Deng1,*, Hengmin Cui1,2, Jing Fang1,2, Zhicai Zuo1,2, Junliang Deng1,2, Yinglun Li1,2, Xun Wang1,2 and Ling Zhao1,2

1College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China

2Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China

*These authors contributed equally to this work

Correspondence to:

Hengmin Cui, email: cui580420@sicau.edu.cn

Keywords: inflammation; inflammatory signaling pathways; chemokines; cytokines; organ diseases

Received: April 19, 2017     Accepted: November 03, 2017     Published: December 14, 2017

ABSTRACT

Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling pathways, most commonly the NF-κB, MAPK, and JAK-STAT pathways. Here, we review inflammatory responses within organs, focusing on the etiology of inflammation, inflammatory response mechanisms, resolution of inflammation, and organ-specific inflammatory responses.


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