Regulation and clinical significance of O-GlcNAc transferase in cancer

Xinling Zhang; Yuchao Gu; Wengong Yu; Hui Liang

doi:10.18632/oncotarget.23132

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Regulation and clinical significance of O-GlcNAc transferase in cancer

Xinling Zhang, Yuchao Gu, Wengong Yu and Hui Liang _

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Abstract

Xinling Zhang1, Yuchao Gu2, Wengong Yu2 and Hui Liang1

1The Institute of Human Nutrition, Medical College of Qingdao University, Qingdao 266021, China

2Key Laboratory of Marine Drugs, Chinese Ministry of Education, Key Laboratory of Glycoscience and Glycotechnology of Shandong Province; School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

Correspondence to:

Hui Liang, email: [email protected]

Xinling Zhang, email: [email protected]

Keywords: OGT; O-GlcNAcylation; expression; protein stability; activity

Received: June 14, 2017 Accepted: November 03, 2017 Published: January 02, 2018

ABSTRACT

O-GlcNAc Transferase (OGT) resides in both cytosolic and nuclear compartments and catalyzes O-GlcNAcylation of myriad proteins. Numerous excellent reviews concerning roles of OGT in organismal and cellular physiology have exist, and aberrant OGT and protein O-GlcNAcylation have been implicated in progression and metastasis of different cancer types. Thus, understanding the regulation mechanisms of OGT and O-GlcNAcylation in tumor cells and their difference compared to non-tumor cells may elucidate new mechanisms related to tumor generation and development, could provide a new marker to diagnosis and prognosis in patients with cancer and indicate a new target to cancer chemotherapy. While it has become evident that OGT plays critical roles in cancers, it remains unclear how they are deregulated. This review provides an overview of our current knowledge about the known/potential regulation of OGT, and also discusses the inhibition of OGT as a potential novel therapeutic target for cancer treatment.

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Regulation and clinical significance of O-GlcNAc transferase in cancer

Abstract