Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients

Lehui Du; Wei Yu; Xiangkun Dai; Nana Zhao; Xiang Huang; Fang Tong; Fang Liu; Yurong Huang; Zhongjian Ju; Wei Yang; Xiaohu Cong; Chuanbin Xie; Xiaoliang Liu; Lanqing Liang; Yanan Han; Baolin Qu

doi:10.18632/oncotarget.22982

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Research Papers:

Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients

Lehui Du, Wei Yu, Xiangkun Dai, Nana Zhao, Xiang Huang, Fang Tong, Fang Liu, Yurong Huang, Zhongjian Ju, Wei Yang, Xiaohu Cong, Chuanbin Xie, Xiaoliang Liu, Lanqing Liang, Yanan Han and Baolin Qu _

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Oncotarget. 2018; 9:958-968. https://doi.org/10.18632/oncotarget.22982

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Abstract

Lehui Du1,*, Wei Yu1,*, Xiangkun Dai1,*, Nana Zhao1, Xiang Huang1, Fang Tong1, Fang Liu1, Yurong Huang1, Zhongjian Ju1, Wei Yang1, Xiaohu Cong1, Chuanbin Xie1, Xiaoliang Liu1, Lanqing Liang1, Yanan Han1 and Baolin Qu1

1Department of Radiation Oncology, Chinese PLA General Hospital, Beijing 100853, China

*These authors contributed equally to this work

Correspondence to:

Baolin Qu, email: [email protected]

Keywords: radiation pneumonitis; ERCC1; ERCC2; XRCC1; lung cancer

Received: June 02, 2017 Accepted: November 08, 2017 Published: December 05, 2017

ABSTRACT

A total of 149 lung cancer patients were recruited to receive intensity modulated radiation therapy (IMRT). The association of developing radiation pneumonitis (RP) with genetic polymorphism was evaluated. The risks of four polymorphic sites in three DNA repair related genes (ERCC1, rs116615:T354C and rs3212986:C1516A; ERCC2, rs13181:A2251C; XRCC1, rs25487:A1196G) for developing grade ≥ 2 RP were assessed respectively. It was observed that ERCC1 T354C SNP had a significant effect on the development of grade ≥ 2 RP (CT/TT vs. CC, adjusted HR = 0.517, 95% CI, 0.285–0.939; adjusted P = 0.030). It is the first time demonstrating that CT/TT genotype of ERCC1 354 was significantly associated with lower RP risk after radio therapy.

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Research Papers:

Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients

Abstract