Protective role of STVNa in myocardial ischemia reperfusion injury by inhibiting mitochondrial fission

Xiaoou Sun; Yingying Yang; Yanxiang Xie; Xingjuan Shi; Lijie Huang; Wen Tan

doi:10.18632/oncotarget.22969

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Protective role of STVNa in myocardial ischemia reperfusion injury by inhibiting mitochondrial fission

Xiaoou Sun, Yingying Yang, Yanxiang Xie, Xingjuan Shi, Lijie Huang and Wen Tan _

PDF | HTML | How to cite

Oncotarget. 2018; 9:1898-1905. https://doi.org/10.18632/oncotarget.22969

Metrics: PDF 1968 views | HTML 2529 views | ?

Abstract

Xiaoou Sun1, Yingying Yang2, Yanxiang Xie2, Xingjuan Shi3, Lijie Huang2 and Wen Tan1

1Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China

2School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China

3Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing 210096, China

Correspondence to:

Wen Tan, email: [email protected]

Keywords: STVNa; mitochondrial; ischemia reperfusion injury; cardioprotective

Received: May 30, 2017 Accepted: November 14, 2017 Published: December 05, 2017

ABSTRACT

It has been reported that isosteviol, a widely known sweeteners, can protect against myocardial ischemia-reperfusion (IR) injury in isolated guinea pig heart. Here, we aim to confirm the cardioprotective effect of its sodium salt, isosteviol sodium (STVNa), against IR injury and its potential molecular mechanism in H9c2 cardiomyocytes. STVNa significantly improved cell viability, restored mitochondrial membrane potential, decreased cellular reactive oxygen species generation, and inhibited cell apoptosis. Furthermore, STVNa treatment changed the morphology of mitochondria from fragmented, discontinuous forms to normal elongated, tubular forms. Cyto-immunofluorescence and western blot analysis revealed that STVNa inhibited mitochondrial fission proteins dynamin-related protein 1 (Drp1), and mitochondrial fission 1 (Fis1), thus plays a key role in cardioprotection. These findings, for the first time, suggest that STVNa can protect against myocardial IR injury through reverse mitochondrial fission.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 22969

Publication Alerts

Research Papers:

Protective role of STVNa in myocardial ischemia reperfusion injury by inhibiting mitochondrial fission

Abstract