Oncotarget

Reviews:

Platelet-inspired medicine for tumor therapy

Jie Yang, Shujun Wang, Ping Liu, Lu Dai, Baoan Chen _, Jianfeng Luan and Jiaying Zhou

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Oncotarget. 2017; 8:115748-115753. https://doi.org/10.18632/oncotarget.22853

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Abstract

Jie Yang1,*, Shujun Wang2,*, Ping Liu1, Lu Dai1,3, Baoan Chen1, Jianfeng Luan2 and Jiaying Zhou4

1Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China

2Department of Blood Transfusion, Nanjing General Hospital of PLA, Nanjing, People’s Republic of China

3Department of Bioengineering, University of California, Berkeley, CA, United States of America

4Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Baoan Chen, email: cba8888@hotmail.com

Keywords: platelet; tumor; drug-loaded system

Received: September 15, 2017    Accepted: November 13, 2017    Published: December 01, 2017

ABSTRACT

As the number of patients with tumor increases dramatically recent years, traditional therapies expose more and more problems which can even lead to death. Many researchers and clinicians quest for an efficient drug delivery system to deal with tumor as a result. With the researches further develop, we find that platelet can interact with tumor cells through a variety of ways. So it can be used as a carrier broadly to deliver different anti-tumor drugs for tumor treatment. In the present review, we summarize the interaction of tumor cells and platelet. At the same time, we focus on recent progress on the application of platelet drug-loaded system in the anti-tumor prospects.


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