Research Papers:
Long non-coding RNA n326322 promotes the proliferation and invasion in nasopharyngeal carcinoma
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Abstract
Mingyu Du1,4,*, Teng Huang2,*, Jing Wu4, Jia-Jia Gu4, Nan Zhang4, Kai Ding1, Lu-Xi Qian3, Zhi-Wei Lu3, Wen-Jun Zhang3, Xiao-Kang Tian1, Xia He1,4 and Li Yin4
1Xuzhou Medical University, Xuzhou, Jiangsu, China
2Department of Radiation Oncology, Jiangsu Province Hospital of TCM, Nanjing, Jiangsu, China
3The Fourth Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China
4Jiangsu Cancer Hospital and Jiangsu Institue of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China
*These authors contributed equally to this work
Correspondence to:
Xia He, email: [email protected]
Li Yin, email: [email protected]
Keywords: nasopharyngeal carcinoma; lncRNA-n326322; invasion
Received: May 01, 2017 Accepted: November 05, 2017 Published: December 01, 2017
ABSTRACT
Long non-coding RNAs (lncRNAs) have been reported to perform significant roles in cancer development and progression. Our research has found that a novel lncRNA n326322 was higher in nasopharyngeal carcinoma (NPC) cells. Moreover, the gain and loss of functional approaches revealed that the overexpression of lncRNA-n326322 promoted NPC cell proliferation and invasion, whereas the downregulation of lncRNA-n326322 suppressed cell proliferation and invasion. Further experiments demonstrated that potential mechanism may be associated with the activation of PI3K/AKT and ERK/MAPK pathways. Taken together, these results indicate that lncRNA-n326322 is associated with tumorigenesis of NPC.
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