Oncotarget

Research Papers:

Long non-coding RNA n326322 promotes the proliferation and invasion in nasopharyngeal carcinoma

Mingyu Du, Teng Huang, Jing Wu, Jia-Jia Gu, Nan Zhang, Kai Ding, Lu-Xi Qian, Zhi-Wei Lu, Wen-Jun Zhang, Xiao-Kang Tian, Xia He _ and Li Yin

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Oncotarget. 2018; 9:1843-1851. https://doi.org/10.18632/oncotarget.22828

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Abstract

Mingyu Du1,4,*, Teng Huang2,*, Jing Wu4, Jia-Jia Gu4, Nan Zhang4, Kai Ding1, Lu-Xi Qian3, Zhi-Wei Lu3, Wen-Jun Zhang3, Xiao-Kang Tian1, Xia He1,4 and Li Yin4

1Xuzhou Medical University, Xuzhou, Jiangsu, China

2Department of Radiation Oncology, Jiangsu Province Hospital of TCM, Nanjing, Jiangsu, China

3The Fourth Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China

4Jiangsu Cancer Hospital and Jiangsu Institue of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China

*These authors contributed equally to this work

Correspondence to:

Xia He, email: hexiabm@163.com

Li Yin, email: yinli_2012@126.com

Keywords: nasopharyngeal carcinoma; lncRNA-n326322; invasion

Received: May 01, 2017     Accepted: November 05, 2017     Published: December 01, 2017

ABSTRACT

Long non-coding RNAs (lncRNAs) have been reported to perform significant roles in cancer development and progression. Our research has found that a novel lncRNA n326322 was higher in nasopharyngeal carcinoma (NPC) cells. Moreover, the gain and loss of functional approaches revealed that the overexpression of lncRNA-n326322 promoted NPC cell proliferation and invasion, whereas the downregulation of lncRNA-n326322 suppressed cell proliferation and invasion. Further experiments demonstrated that potential mechanism may be associated with the activation of PI3K/AKT and ERK/MAPK pathways. Taken together, these results indicate that lncRNA-n326322 is associated with tumorigenesis of NPC.


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