Oncotarget

Meta-Analysis:

The efficacy and safety of first-line therapies for preventing chronic post-surgical pain: a network meta-analysis

Jie Ning, Jing Luo, Zengdong Meng, Chong Luo, Gang Wan, Jie Liu, Sanrong Wang, Xingye Lian, ND Melgiri, Yang Sun and Rongzhong Huang _

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Oncotarget. 2018; 9:32081-32095. https://doi.org/10.18632/oncotarget.22611

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Abstract

Jie Ning1,*, Jing Luo1,*, Zengdong Meng2, Chong Luo2, Gang Wan2, Jie Liu2, Sanrong Wang4, Xingye Lian2, ND Melgiri6, Yang Sun5 and Rongzhong Huang3,4

1Department of Pain Medicine, The First People’s Hospital of Yunnan Province, Yunnan, Kunming, China

2Department of Orthopedics, The First People’s Hospital of Yunnan Province, Yunnan, Kunming, China

3Department of Gerontology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Jiangbei, China

4Department of Pain Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Jiangbei, China

5Institute of Ultrasound Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Jiangbei, China

6Impactys Foundation for Biomedical Research, San Diego, CA, United States of America

*Co-authors

Correspondence to:

Rongzhong Huang, email: rzhuang@live.com

Yang Sun, email: sy19850905@126.com

Keywords: chronic post-surgical pain; CPSP; nefopam; mexiletine; pregabalin

Received: April 08, 2017     Accepted: July 30, 2017     Epub: November 03, 2017     Published: August 10, 2018

ABSTRACT

Background: Due to conflicting evidence regarding first-line therapies for chronic post-surgical pain (CPSP), here we comparatively evaluated the efficacy and safety of first-line therapies for the prevention of CPSP.

Materials and Methods: MEDLINE, EMBASE, and Cochrane CENTRAL databases were searched for randomized, controlled trials (RCTs) of systemic drugs measuring pain three months or more post-surgery. Pairwise meta-analyses (a frequentist technique directly comparing each intervention against placebo) and network meta-analyses (a Bayesian technique simultaneously comparing several interventions via an evidence network) compared the mean differences for primary efficacy (reduction in all pain), secondary efficacy (reduction in moderate or severe pain), and primary safety (drop-out rate from treatment-related adverse effects). Ranking probabilities from the network meta-analysis were transformed using surface under the cumulative ranking analysis (SUCRA). Sensitivity analyses evaluated the impact of age, gender, surgery type, and outlier studies.

Results: Twenty-four RCTs were included. Mexiletine and ketamine ranked highest in primary efficacy, while ketamine and nefopam ranked highest in secondary efficacy. Simultaneous SUCRA-based rankings of the interventions according to both efficacy and safety revealed that nefopam and mexiletine ranked highest in preventing CPSP. Through the sensitivity analyses, gabapentin and ketamine remained the most-highly-ranked in terms of efficacy, while nefopam and ketamine remained the most-highly-ranked in terms of safety.

Conclusions: Nefopam and mexiletine may be considered as first-line therapies for the prevention of CPSP. On account of the paucity of evidence available on nefopam and mexiletine, gabapentin and ketamine may also be considered. Venlafaxine is not recommended for the prevention of CPSP.


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