Oncotarget

Research Papers:

Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer

Yajun Luo, Cheng Wang, Peng Yong, Pengcheng Ye, Zilin Liu, Zhiming Fu, Fei Lu, Wanping Xiang, Wang Tan and Jiangwei Xiao _

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Oncotarget. 2017; 8:112530-112549. https://doi.org/10.18632/oncotarget.22486

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Abstract

Yajun Luo1,*, Cheng Wang2,*, Peng Yong3,*, Pengcheng Ye1, Zilin Liu1, Zhiming Fu1, Fei Lu1, Wanping Xiang1, Wang Tan1 and Jiangwei Xiao1,4

1The Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China

2The Department of Pediatric Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China

3The Department of HPB Surgery, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China

4The Department of General Surgery, Chengdu First People’s Hospital, Chengdu, Sichuan, People’s Republic of China

*These authors contributed equally to this work

Correspondence to:

Jiangwei Xiao, email: xiaojiangwei@126.com

Keywords: long non-coding RNA, gastric cancer, SLC7A11-AS1, SLC7A11, proliferation

Received: December 12, 2016     Accepted: September 30, 2017     Published: November 07, 2017

ABSTRACT

Many lncRNA and mRNA sense-antisense transcripts have been systematically identified in malignant cells. However, the molecular mechanisms of most lncRNA-mRNA pairs in gastric cancer remain largely unknown. We found the gastric cancer-associated lncRNA SLC7A11-AS1 and coding transcript mRNA SLC7A11 in human gastric cancer specimens by microarray. SLC7A11-AS1, antisense to SLC7A11, is significantly down-regulated in gastric cancer and could promote tumor growth in vitro and in vivo. The effects of SLC7A11-AS1 depend on the regulation of SLC7A11 via the ASK1-p38MAPK/JNK signaling pathway. These findings suggest that decreased expression of SLC7A11-AS1 contributes to the progression of gastric cancer and may be a novel diagnostic biomarker and effective therapeutic target in gastric cancer patients.


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