Oncotarget

Research Papers:

MiR-20a-5p promotes radio-resistance by targeting NPAS2 in nasopharyngeal cancer cells

Fangfang Zhao, Youguang Pu, Liting Qian, Chunbao Zang, Zhenchao Tao and Jin Gao _

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Oncotarget. 2017; 8:105873-105881. https://doi.org/10.18632/oncotarget.22411

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Abstract

Fangfang Zhao1,*, Youguang Pu1,*, Liting Qian2, Chunbao Zang3, Zhenchao Tao3 and Jin Gao2

1The Institute of Cancer Research, Anhui Cancer Hospital, West Branch of Anhui Provincial Hospital, Anhui Medical University, Hefei 230031, Anhui, China

2Department of Radiation Oncology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230031, Anhui, China

3Department of Radiation Oncology, Anhui Cancer Hospital, West Branch of Anhui Provincial Hospital, Anhui Medical University, Hefei 230031, Anhui, China

*These authors have contributed equally to this work

Correspondence to:

Jin Gao, email: gj11667@126.com

Keywords: nasopharyngeal cancer; miR-20a-5p; NPAS2; radio-resistance

Received: August 24, 2016     Accepted: September 13, 2017     Published: November 11, 2017

ABSTRACT

MicroRNAs (miRNAs) are key players of gene expression involved in diverse biological processes including the cancer radio-resistance, which hinders the effective cancer therapy. Here we found that the miR-20a-5p level is significantly up-regulated in radio-resistant nasopharyngeal cancer (NPC) cells via an RNA-seq and miR-omic analysis. Moreover, we identified that the neuronal PAS domain protein 2 (NPAS2) gene is one of the targets of miR-20a-5p. The involvement of miR-20a-5p and NPAS2 with NPC radio-resistance was further validated by either down- or up-regulation of their levels in NPC cell lines. Taken together, these results not only reveal novel insights into the NPC radio-resistance, but also provide hints for an effective therapeutic strategy to fight against NPC radio-resistance.


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