Oncotarget

Research Papers:

Genetic variations in TERC and TERT genes are associated with lung cancer risk in a Chinese Han population

Gang Ye, Nan Tan, Chenyang Meng, Jingjie Li, Li Jing, Mengdan Yan, Tianbo Jin and Fulin Chen _

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Oncotarget. 2017; 8:110145-110152. https://doi.org/10.18632/oncotarget.22329

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Abstract

Gang Ye1,2,*, Nan Tan3,*, Chenyang Meng4, Jingjie Li1, Li Jing1, Mengdan Yan1, Tianbo Jin1,5 and Fulin Chen1

1Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China

2First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832008, P. R. China

3Department of Cadre’s Ward, Xi’an No.1 Hospital, Xi’an, Shaanxi 710002, China

4Graduate School of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China

5Xi’an Tianqin Precision Medical Institute, Xi’an, Shaanxi 710075, China

*These authors have contributed equally to this work

Correspondence to:

Fulin Chen, email: chenfl@nwu.edu.cn

Tianbo Jin, email: jintianbo@gmail.com

Keywords: single nucleotide polymorphism (SNP); TERC; TERT; lung cancer

Received: June 20, 2017    Accepted: September 05, 2017    Published: November 06, 2017

ABSTRACT

The study was aimed to explore whether the TERT and TERC polymorphisms are associated with the lung cancer risk. Five TERC and TERT polymorphisms were genotyped from 554 lung cancer patients and 603 healthy controls. We used χ2 test, genetic model, linkage disequilibrium (LD) and haplotype analyses to evaluate the association between the polymorphisms and lung cancer risk. We found that the allele “C” of rs10936599 (TERC) and the allele “T” of rs10069690 (TERT) were associated with increased risk of lung cancer (OR = 1.32, 95% CI: 1.12-1.55, P = 0.001; OR = 1.41, 95% CI: 1.14-1.76, P = 0.002, respectively). The genotype of “CC” of rs10936599, genotype “CT” of rs10069690 and genotype “GG and “AG” of rs2853677 were also associated with increased the risk of lung cancer. In addition, rs10936599 under the dominant, recessive and log-additive models; rs10069690 under the dominant, overdominant and log-additive models; rs2853677 under the dominant and log-additive models were found to be associated with increased lung cancer risk. The SNP rs2242652 was found to be associated with an increased lung cancer risk under the dominant and overdominant models without adjustment. The haplotype “TA” of TERT was also associated with an increased risk of lung cancer. Our study indicated that rs10936599 (TERC) and rs10069690, rs2242652 and rs2853677 in TERT and haplotype “TA” of TERT were revealed as risk factors of lung cancer in a Chinese Han population. However, it required to verify our result and investigate the function genetic variants and mechanism of lung cancer.


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