Research Papers:
Serum corin is associated with the risk of chronic heart failure
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Abstract
Zongliang Yu1,*, Xiang Lu2,*, Weiting Xu3,*, Mengchao Jin3, Yifei Tao3 and Xiang Zhou3
1Department of Cardiology, The First People's Hospital of Kunshan Affiliated to Jiangsu University, Kunshan, China
2Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China
3Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China
*These authors have contributed equally to this work
Correspondence to:
Xiang Zhou, email: [email protected]
Keywords: chronic heart failure; corin; risk
Received: August 16, 2017 Accepted: October 13, 2017 Published: November 01, 2017
ABSTRACT
It has been well documented that corin is a critical protease involved in the regulation of blood pressure and cardiac function. We performed a case-control study to determine whether serum corin is associated with the risk of chronic heart failure (CHF). We included 484 consecutive CHF patients and 484 control subjects to investigate the potential relationship between serum corin and CHF using logistic regression analysis. Compared with healthy controls, the CHF patients were more likely to have histories of hypertension and diabetes, and had higher levels of N-terminal pro-brain natriuretic peptide and lower levels of corin. The odds ratios of ischemic and non-ischemic HF were significantly reduced with the growing levels of serum corin after multivariate adjustment. Moreover, the decrease in serum corin levels seemed to be associated with the severity of CHF. In conclusion, our study suggested that serum corin levels were reduced in CHF patients and inversely correlated with the incidence of ischemic and non-ischemic HF.
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