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This article is currently undergoing investigation. AUGUST 2018: This article is currently undergoing investigation due to an ongoing author’s dispute between the last and first author about the format of the first author's name.

The value of lncRNA FENDRR and FOXF1 as a prognostic factor for survival of lung adenocarcinoma

Antonio Herrera-Merchan _, Marta Cuadros, Maria Isabel Rodriguez, Sandra Rodriguez, Raul Torres, Marcos Estecio, Isabel F. Coira, Claudia Loidi, Monica Saiz, Pedro Carmona-Saez, Pedro P. Medina

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Abstract

Antonio Herrera-Merchan1,2,*, Marta Cuadros1,3,*, Maria Isabel Rodriguez1,2, Sandra Rodriguez4, Raul Torres4, Marcos Estecio5, Isabel F. Coira1,2, Claudia Loidi6, Monica Saiz6, Pedro Carmona-Saez1 and Pedro P. Medina1,2

1Centre for Genomics and Oncological Research, PTS Granada, Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica (GENYO), Granada, Spain

2Department of Biochemistry and Molecular Biology I, University of Granada, Granada, Spain

3Department of Biochemistry and Molecular Biology III e Immunology, University of Granada, Granada, Spain

4Molecular Cytogenetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre-CNIO, Madrid, Spain

5Department of Epigenetics and Molecular Carcinogenesis, UT MD Anderson Cancer Center, Houston, TX, USA

6Pathological Anatomy, Universitary Hospital Cruces, University of Pais Vasco, Spain

*These authors have contributed equally to this work

Correspondence to:

Pedro P. Medina, email: pedromedina@ugr.es

Keywords: lncRNA; FENDRR; FOXF1; lung cancer; methylation

Received: June 09, 2017     Accepted: October 02, 2017     Published: October 27, 2017

ABSTRACT

It is increasingly evident that non-coding RNAs play a significant role in tumour development. However, we still have a limited knowledge of the clinical significance of long non-coding RNAs (lncRNAs) in lung cancer. The FENDRR is a long coding RNA (also named FOXF1-AS1) located in the vicinity of the protein-coding gene FOXF1 at 16q24.1 chromosomal region. The present study aimed to define the clinic pathological significance of the long-non-coding RNA FENDRR in lung adenocarcinomas. FENDRR expression measured by quantitative PCR was found significantly downregulated (p<0.001) in lung adenocarcinoma samples in comparison with their normal adjacent tissues (n=70). RNA in situ hybridization (RNA-FISH) corroborated independently the down-regulation of FENDRR. Interestingly, the expression of FENDRR correlated positively (p<0.001) with the expression of its protein-coding neighbor gene FOXF1. Additionally, FOXF1 expression was also found downregulated in adenocarcinomas compared to normal samples (p<0.001) and its expression was significantly correlated with overall survival alone (p=0.003) or in combination with FENDRR expression (p=0.01). In conclusion, our data support that FENDRR and FOXF1 expression is decreased in lung adenocarcinoma and should be considered as new potential diagnostic/prognosis biomarkers.


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