Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
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1Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461
2Department of Medicine (Oncology) Albert Einstein College of Medicine, Bronx, NY 10461
Keywords: Senescence, 4E-BP1, mTORC1, p53, discodermolide
Received: February 22, 2011; Accepted: February 22, 2011; Published: February 22, 2011;
Susan Band Horwitz, e-mail:
Hayley McDaid, e-mail:
Senescence is a valid tumor suppressive mechanism in cancer. Accelerated cell senescence describes the growth arrested state of cells that have been treated with anti-tumor drugs, such as doxorubicin that induce a DNA damage response. Discodermolide, a microtubule-stabilizing agent, is a potent inducer of accelerated cell senescence. Resistance to discodermolide is mediated via resistance to accelerated cell senescence, and is associated with reduced expression of the mTORC1 substrate, 4E-BP1 and increased expression of p53 . Although the association of p53 with senescence induction is well-characterized, senescence reversion in the presence of high expression of p53 has not been well-documented. Furthermore, studies addressing the role of mTOR signaling in regulating senescence have been limited and recent data implicate a novel, senescence-associated role for 4E-BP1 in crosstalk with the transcription factor p53. This research perspective will address these somewhat contradictory findings and summarize recent research regarding senescence and mTORC1 signaling.
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