Oncotarget

Research Papers:

Higher expression of FOXOs correlates to better prognosis of bladder cancer

Ying Zhang, Linpei Jia, Ying Zhang, Wei Ji and Hai Li _

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Oncotarget. 2017; 8:96313-96322. https://doi.org/10.18632/oncotarget.22029

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Abstract

Ying Zhang1, Linpei Jia2, Ying Zhang3, Wei Ji4 and Hai Li5

1Department of Pathology, China-Japan Union Hospital of Jilin University, Changchun 130033, P.R. China

2Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing 100000, P.R. China

3Department of Neurology, First Hospital of Jilin University, Changchun 130021, P.R. China

4Department of Vascular Surgery, Jilin Provincial People’s Hospital, Changchun 130000, P.R. China

5Department of Urology, China-Japan Union Hospital of Jilin University, Changchun 130033, P.R. China

Correspondence to:

Hai Li, email: muandkamu_2012@aliyun.com

Keywords: bladder cancer; forkhead box class O; clinicopathological characteristics; prognosis

Received: August 30, 2017    Accepted: September 24, 2017    Published: October 24, 2017

ABSTRACT

Background: We aimed to explore the expression of forkhead box class O (FOXO) and relations between expressions of FOXOs and clinicopathological characteristics and prognosis of bladder cancer.

Methods: We enrolled a cohort of 276 patients with bladder cancer in our study. Expressions of FOXOs in bladder cancer tissue and adjacent tissue were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC). Correlations between expression of FOXOs and clinicopathological characteristics and prognosis were analyzed. The relationship between expression of FOXOs and survival time of patients with bladder cancer was analyzed by the Kaplan-Meier survival analysis and the Log-rank test; individual variables which may affect the prognosis of bladder cancer were detected by the Cox proportional hazard regression model.

Results: Compared with bladder cancer tissue, a higher expression of FOXOs was detected in paracancerous tissue. We found significant associations between histological grade and the expressions of FOXOs, clinical stage and the expressions of FOXOs, and lymph node metastasis and the expressions of FOXOs (all P < 0.05). When used for diagnosing bladder cancer, the mRNA expression of FOXO1/3/4 produced cut off values of 1.475, 1.305, and 1.295, respectively, exhibiting relatively high specificity and sensitivity. The Kaplan-Meier curves indicated that patients with a higher expression of FOXOs tended to have a longer overall survival than those with lower expression. The Cox regression analysis revealed that lymph node metastasis, high clinical stage, and low expression of FOXOs were independent risk factors for bladder cancer prognosis.

Conclusion: Our results indicate that the expression of FOXOs is closely correlated with clinicopathological characteristics and prognosis of bladder cancer.


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