Methylated  claudin-11  associated with metastasis and poor survival of colorectal cancer

Jinyun Li; Chongchang Zhou; Shumin Ni; Shaomin Wang; Chao Ni; Ping Yang; Meng Ye

doi:10.18632/oncotarget.21997

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Methylated claudin-11 associated with metastasis and poor survival of colorectal cancer

Jinyun Li, Chongchang Zhou, Shumin Ni, Shaomin Wang, Chao Ni, Ping Yang and Meng Ye _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:96249-96262. https://doi.org/10.18632/oncotarget.21997

Metrics: PDF 1204 views | HTML 2661 views | ?

Abstract

Jinyun Li1, Chongchang Zhou2, Shumin Ni1, Shaomin Wang1, Chao Ni3, Ping Yang3 and Meng Ye1

1Department of Oncology and Hematology, Affiliated Hospital, Medical School of Ningbo University, Ningbo, Zhejiang 315000, China

2Department of Otorhinolaryngology Head and Neck Surgery, Lihuili Hospital of Ningbo University, Ningbo 315040, Zhejiang, China

3Medical School, Ningbo University, Ningbo, Zhejiang 315211, China

Correspondence to:

Meng Ye, email: [email protected]

Keywords: DNA methylation; colorectal cancer; claudin-11; metastasis; progression free survival

Received: June 06, 2017 Accepted: August 17, 2017 Published: October 23, 2017

ABSTRACT

As one of crucial epigenetic modification, DNA methylation plays an important role during the carcinogenesis of colorectal cancer (CRC). In the current study, we used a human genome methylation array to detect the aberrant methylation genes in CRC. We further identified the hypermethylation of claudin-11 (CLDN11) and proved inverse correlation between CLDN11 methylation and its expression in CRC. In vitro experiments showed debased migration ability of colonic cancer cells in accompany with the converted methylation of CLDN11 after colonic cancer cells treated with demethylation agent, 5-aza-2’-deoxycytidine. Besides, our results also represented that hypermethylation of CLDN11 was associated with increased metastatic potential of CRC and with low progression free survival (PFS) of CRC. In conclusion, our findings supported that the hypermethylated CLDN11 is associated with metastasis of CRC and prognosis of poor survival of CRC.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 21997

Publication Alerts

Research Papers:

Methylated claudin-11 associated with metastasis and poor survival of colorectal cancer

Abstract