Clinical significance and biological function of fucosyltransferase 2 in lung adenocarcinoma

Wenyuan Zhou; Huijun Ma; Guoqing Deng; Lili Tang; Jianxin Lu; Xiaoming Chen

doi:10.18632/oncotarget.21896

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Research Papers:

Clinical significance and biological function of fucosyltransferase 2 in lung adenocarcinoma

Wenyuan Zhou, Huijun Ma, Guoqing Deng, Lili Tang, Jianxin Lu _ and Xiaoming Chen

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Oncotarget. 2017; 8:97246-97259. https://doi.org/10.18632/oncotarget.21896

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Abstract

Wenyuan Zhou1,2,*, Huijun Ma1,2,3,*, Guoqing Deng1,2, Lili Tang1,2, Jianxin Lu1,2,4 and Xiaoming Chen1,2

1Institute of Glycobiological Engineering/School of Laboratory Medicine & Life Sciences, Wenzhou Medical University, Wenzhou, China

2Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine & Life Sciences, Wenzhou Medical University, Wenzhou, China

3Department of Laboratory, Women and Children’s Hospital of Qingdao, Qingdao, China

4Hangzhou Medical College, Hangzhou, Zhejiang, China

*These authors have contributed equally to this work

Correspondence to:

Jianxin Lu, email: [email protected]

Xiaoming Chen, email: [email protected]

Keywords: fucosyltransferases; FUT2; lung adenocarcinaoma; proliferation; metastasis

Received: March 22, 2017 Accepted: September 05, 2017 Published: October 19, 2017

ABSTRACT

Fucosylation, which is catalyzed by fucosyltransferases (FUTs), is one of the most important glycosylation events involved in cancer. Studies have shown that fucosyltransferase 8 (FUT8) is overexpressed in NSCLC and promotes lung cancer progression. However, there are no reports about the pathological role of fucosyltransferase 2 (FUT2) in lung cancer. To identify FUT2 associated with lung cancer, the expression and clinical significance of FUT2 in lung cancer was investigated by Real-Time PCR, Immunohistochemistry and Western Blot. In addition, we investigated the effect of knockdown FUT2 in lung adenocarcinoma cells. The results showed that the expression of FUT2 in lung adenocarcinoma is higher than that in adjacent noncancerous tissues. Knocking down FUT2 in A549 and H1299 cells decreased cell proliferation, migration and invasion, and increased cell apoptosis compared to corresponding control cells. Furthermore, Western Blot showed that knockdown FUT2 can impact the expression of migration-associated and apoptosis-associated proteins in A549 cells. Our results suggest that FUT2 may be associated with lung adenocarcinoma development and thus is a potential biomarker or/and therapeutic target in lung adenocarcinoma.

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Research Papers:

Clinical significance and biological function of fucosyltransferase 2 in lung adenocarcinoma

Abstract