Clinical Research Papers:
Combination of primary tumor location and mismatch repair status guides adjuvant chemotherapy in stage II colon cancer
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Abstract
Lin Yang1,2,3,*, Wenzhuo He1,2,3,*, Qiong Yang4,*, Pengfei Kong1,2,3, Qiankun Xie1,2,3, Chang Jiang1,2,3, Bei Zhang1,2,3 and Liang Ping Xia1,2,3
1Sun Yat-Sen University Cancer Center, Guangzhou, China
2State Key Laboratory of Oncology in Southern China, Guangzhou, China
3Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
4Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
*These authors contributed equally to this work and share the first authorship
Correspondence to:
Liang Ping Xia, email: [email protected]
Bei Zhang, email: [email protected]
Keywords: primary tumor location, mismatch repair, survival, adjuvant chemotherapy, colon cancer
Received: August 14, 2017 Accepted: September 22, 2017 Published: October 12, 2017
ABSTRACT
Background: Current opinions on the benefits of adjuvant chemotherapy for stage II colon cancer are divided and reformative election of these patients is required. We examined whether the primary tumor location based on mismatch repair status and other risk factors could better inform the current guideline.
Materials and Methods: A total of 673 consecutive patients with stage II colon cancer were included in the analysis. Differences in the common clinicopathological factors between left-sided colon cancer and right-sided colon cancer were analyzed using Fisher’s exact analysis. Kaplan–Meier analysis was used to distinguish the survival difference by primary tumor location and/or MMR status.
Results: RCC had a shorter overall survival (P = 0.001) and Disease-free survival (P = 0.050) than LCC but was associated with survival benefit from adjuvant chemotherapy (P = 0.001 and P = 0.011 for OS and DFS, respectively). Mismatch repair-proficient had a shorter OS (P = 0.036) and disease free survival (P = 0.034) than mismatch-repair deficient but chemotherapy improved the OS (P = 0.007). When the primary tumor location and MMR status were combined, the PMMR/RCC was the only subgroup that could benefit from adjuvant chemotherapy (P < 0.001 and P = 0.002 for OS and DFS, respectively). Other tumors such as DMMR/RCC, DMMR/LCC, and PMMR/LCC did not benefit.
Conclusions: The observed survival benefits in PMMR/RCC patients treated with adjuvant chemotherapy will allow better selection of patients for chemotherapy who are in stage II.
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