Oncotarget

Meta-Analysis:

Prognostic role of long non-coding RNA LINC00152 in Chinese cancer patients: a meta-analysis

Liyang Liu, Jianfei Wen, Xi Gu, Dongdong Wu, Ming Lu and Qinghong Zhao _

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Oncotarget. 2017; 8:93227-93235. https://doi.org/10.18632/oncotarget.21838

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Abstract

Liyang Liu1,*, Jianfei Wen2,*, Xi Gu1,*, Dongdong Wu1, Ming Lu1 and Qinghong Zhao1

1Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

2Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

*These authors contributed equally to this work and Co-first authors

Correspondence to:

Qinghong Zhao, email: njzhqh@sina.com

Keywords: LINC00152, cancer, metastasis, prognosis, meta-analysis

Received: July 20, 2017     Accepted: September 21, 2017     Published: October 12, 2017

ABSTRACT

The role of long intergenic non-coding RNA 152 (LINC00152) in predicting the prognosis of cancer has been investigated but results remain inconclusive and inconsistent. A meta-analysis was performed to explore the effect of LINC00152 on cancer prognosis. PubMed and ScienceDirect were searched for suitable studies and the results of 10 studies with a total of 775 patients were pooled. Pooled hazard ratios (HRs) and odds ratios (ORs) were calculated to assess the prognostic value of LINC00152. The results revealed that tumour patients with high LINC00152 expression were more likely to have lymph node metastasis (OR = 2.94, 95% CI 1.97–4.40, P < 0.001) and unfavourable tumour–node–metastasis stage (grade III/IV vs. I/II: OR = 3.07, 95% CI 1.69–5.59, P < 0.001). In addition, high LINC00152 expression levels were significantly associated with poor overall survival (pooled HR = 1.99, 95% CI 1.54–2.56, P < 0.001). The results suggest that high LINC00152 expression may serve as a predictive biomarker for the poor prognosis of various cancers in the Chinese population.


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