Oncotarget

Research Papers:

LncRNA BANCR facilitates vascular smooth muscle cell proliferation and migration through JNK pathway

He Li, Xian Liu, Lan Zhang and Xueqi Li _

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Oncotarget. 2017; 8:114568-114575. https://doi.org/10.18632/oncotarget.21603

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Abstract

He Li1, Xian Liu1, Lan Zhang1 and Xueqi Li1

1Department of Cardiology, The Fourth Hospital of Harbin Medical University, Harbin, China

Correspondence to:

Xueqi Li, email: ueqili@126.com

Keywords: atherosclerosis, vascular smooth muscle cell, lncRNAs, BANCR, JNK

Received: May 31, 2017     Accepted: September 08, 2017     Published: October 07, 2017

ABSTRACT

Deregulated migration and proliferation of vascular smooth muscle cells (VSMCs) acts a crucial role in the pathogenesis of many cardiovascular diseases such as atherosclerosis, coronary heart disease and hypertension. Long noncoding RNAs (lncRNAs) play crucial functional roles in a lot of biological processes such as cell development, cell proliferation, differentiation and invasion. In our study, we demonstrated that the BANCR expression level was upregulated in the atherosclerotic plaques tissues compared to in the normal vessels tissues. TNF-α could emhance the VSMCs proliferation. The expression level of BANCR and p-JNK were upregulated and activated in the proliferating VSMCs. Overexpression of BANCR enhanced VSMCs proliferation and migration. Elevated expression of BANCR induced JNK activation, which can be decreased by the specific JNK inhibitor SP600125. We demonstrated that ectopic expression of BANCR increased the VSMCs proliferation and migration through activating JNK pathway. These data suggested that lncRNA BANCR acts a crucial role in the regulating VSMCs proliferation and migration partly by activating the JNK pathway.


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