Oncotarget

Research Papers:

Untargeted serum metabonomics study of psoriasis vulgaris based on ultra-performance liquid chromatography coupled to mass spectrometry

Li Li _, Chuan-Jian Lu, Ling Han, Jing-Wen Deng, Ze-Hui He, Yu-Hong Yan and Zhong-Zhao Zhang

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Oncotarget. 2017; 8:95931-95944. https://doi.org/10.18632/oncotarget.21562

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Abstract

Li Li1, Chuan-Jian Lu2, Ling Han1, Jing-Wen Deng2, Ze-Hui He3, Yu-Hong Yan2 and Zhong-Zhao Zhang2

1Molecular Biology and Systems Biology Team of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China

2Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China

3Large Data Research Team of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China

Correspondence to:

Li Li, email: Lily_vvv@163.com

Chuan-Jian Lu, email: Luchuanjian888@vip.sina.com

Ling Han, email: Linghan36@163.com

Keywords: psoriasis; metabonomics; LC-MS; biomarker; high-throughput

Received: October 07, 2016     Accepted: August 29, 2017     Published: October 06, 2017

ABSTRACT

Psoriasis is a common, chronic, systemic inflammatory skin disease, the etiology and pathogenesis is unclear. An untargeted high-throughput metabonomics method based on liquid chromatography coupled to mass spectrometry was applied to study the serum metabolic changes in psoriasis vulgaris patients, and to discover serum potential biomarkers for identification, diagnosis and exploring pathogenesis of psoriasis. The serum metabolic profiles from 150 subjects (75 psoriasis patients and 75 healthy controls) were acquired, the raw spectrometric data were processed by multivariate statistical analysis, and 44 potential biomarkers were screened out and identified. The potential biomarkers were mainly involved in glycerophospholipid metabolism, sphingolipid metabolism, arachidonic acid metabolism, bile acid biosynthesis, indicated the pathogenesis of psoriasis may be related to the disturbed metabolic pathways.


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