Oncotarget

Research Papers:

High salt induced hypertension leads to cognitive defect

Cui-Ping Guo, Zhen Wei, Fang Huang, Min Qin, Xing Li, Yu-Man Wang, Qun Wang, Jian-Zhi Wang, Rong Liu, Bin Zhang, Hong-Lian Li and Xiao-Chuan Wang _

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Oncotarget. 2017; 8:95780-95790. https://doi.org/10.18632/oncotarget.21326

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Abstract

Cui-Ping Guo1, Zhen Wei1, Fang Huang1, Min Qin1, Xing Li1, Yu-Man Wang1, Qun Wang1, Jian-Zhi Wang1,2, Rong Liu1, Bin Zhang3, Hong-Lian Li4 and Xiao-Chuan Wang1,2

1Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

2Division of Neurodegenerative Disorders, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, JS 226001, China

3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

4Department of Histology and Embryology, School of Basic Medicine, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Correspondence to:

Xiao-Chuan Wang, email: wxch@mails.tjmu.edu.cn

Hong-Lian Li, email: lihonglian@hust.edu.cn

Keywords: high salt diet; hypertension; cognitive defects; synaptogenesis; cerebral blood flow

Abbreviations: AD: Alzheimer’s disease; BP: blood pressure; SBP: systolic blood pressure; CBF: cerebral blood flow

Received: July 27, 2017     Accepted: August 17, 2017     Published: September 27, 2017

ABSTRACT

Although increasing evidences suggest a relationship between hypertension and brain function for years, it is still unclear whether hypertension constitutes a risk factor for cognitive decline and its underlying mechanism. In the present study, an experimental animal model of hypertension simply by feeding rats with high salt diet was employed. We found that long-term high salt intake caused a marked increase of systolic blood pressure linked to a declined regional cerebral blood flow. Fear conditioning and morris water maze behavioral test revealed that high salt diet induced hippocampal dependent spatial reference memory deficits, while a decreased synaptogenesis without neuronal loss in hippocampus was observed in high salt treated rats. Furthermore, we found that high salt induced a decrease of intracellular calcium, which inactivated CaMK II and resulted in dephosphorylation of CREB at Ser133. These findings suggest a novel etiopathogenic mechanism of cognitive deficit induced by hypertension, which is initiated by high salt diet.


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