The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option
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Fengli Lv1,*, Suling Chen2,*, Lina Wang3,*, Ronghuan Jiang4, Hongjun Tian3, Jie Li3, Yudong Yao5 and Chuanjun Zhuo2,3
1The department of rehabilition, The Second Affiliated Hosptial of Tianjin Medical University, Tianjin, China
2Department of Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou, Zhejiang, China
3Department of Psychiatry, Tianjin Anding Hospital, Tianjin Mental Health Center, Tianjin, China
4Department of Psychological Medicine, Chinese People’s Liberation Army, General Hospital, Chinese People’s Liberation Army Medical School, Beijing, China
5Department of Pharmacology and Physiology, SUNY Downstate Medical Center, Brooklyn, NY, USA
*These authors contributed equally to this work
Chuanjun Zhuo, email: firstname.lastname@example.org
Yudong Yao, email: email@example.com
Jie Li, email: firstname.lastname@example.org
Keywords: microbiota, brain-gut axis, psychiatric disorders, schizophrenia, depression
Received: June 15, 2017 Accepted: August 26, 2017 Published: September 27, 2017
The importance of interactions between the brain and the gastrointestinal tract has been increasingly recognized in recent years. It has been proposed that dysregulation and abnormalities in the brain-gut axis contribute to the etiology of a variety of central nervous system disorders. Particularly, dysbiosis, or impaired microbiota, has been implicated in multiple neurological and psychological disorders. The present paper reviews current evidence and theories concerning the possible mechanisms by which microbiota dysfunction contributes to the pathogenesis of schizophrenia and major depressive disorder. Clinical trials that investigated the possibility of treating both illnesses by correcting and rebalancing microbiota with probiotics are also reviewed. Overall, despite the accumulated knowledge in this field, more studies are warranted and required to further our understanding of the brain-gut axis and the possibility of targeting microbiota as a treatment option for schizophrenia and major depressive disorder.
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