Oncotarget

Clinical Research Papers:

Whether partial colectomy is oncologically safe for patients with transverse colon cancer: a large population-based study

Xu Guan, Zhixun Zhao, Ming Yang, Haipeng Chen, Wei Chen, Zheng Liu, Zheng Jiang, Yinggang Chen, Guiyu Wang & Xishan Wang _

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Oncotarget. 2017; 8:93236-93244. https://doi.org/10.18632/oncotarget.21275

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Abstract

Xu Guan1,*, Zhixun Zhao2,*, Ming Yang1,*, Haipeng Chen3, Wei Chen4, Zheng Liu1, Zheng Jiang1, Yinggang Chen2, Guiyu Wang2 and Xishan Wang1,2

1Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

2Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

3Department of Surgical Oncology, The First Affiliated Clinical Hospital of Qiqihaer Medical University, Qiqihaer, China

4Follow Up Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

*These authors contributed equally to this work

Correspondence to:

Xishan Wang, email: wxshan1208@126.com

Keywords: hemicolectomy, colectomy, transverse colon cancer, survival

Received: October 13, 2016     Accepted: September 09, 2017     Published: September 26, 2017

ABSTRACT

Due to special tumor location and technical difficulty of transverse colon cancer (TCC), partial colectomy (PC) is being widely applied in selected TCC patients, instead of extended hemicolectomy (HC). However, the oncological safety of this less aggressive surgical approach is not well studied. Here, we identified 10344 TCC patients from Surveillance, Epidemiology, and End-Results (SEER) database. The surgical treatment for those patients included PC and HC. Firstly, we compared lymph nodes evaluations between patients treated with HC and PC, including median number of nodes, the rate of nodes ≥ 12 and the rate of node positivity. Then, 5-year cancer specific survival (CSS) was obtained. Kaplan-Meier methods and Cox regression models were performed to assess the correlations between prognostic factors and long-term survival. Despite of less node examined by PC, the rate of node positivity was equal between PC and HC, suggesting node retrieval under PC was adequate to tumor stage. In addition, the 5-year CSS for patients who underwent PC were 67.5%, which was similar to patients who received HC (66.5%). The result after propensity score matching also confirmed the equivalent survival outcome between HC and PC. However, subgroup analyses showed that patients with tumor size ≥ 5 cm could not obtain survival benefit from PC. Furthermore, surgical approach was not considered as independent prognostic factor for TCC patients. Therefore, although PC is a less aggressive surgical approach, it should be a safe and feasible option for selected TCC patients.


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