Mixed subtype thyroid cancer: A surveillance, epidemiology, and end results database analysis

Chunping Liu; Qiuyang Zhao; Zhi Li; Shuntao Wang; Yiquan Xiong; Zeming Liu; Tao Huang

doi:10.18632/oncotarget.21242

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Research Papers:

This article has been corrected. Correction in: Oncotarget. 2018; 9:16274.

Mixed subtype thyroid cancer: A surveillance, epidemiology, and end results database analysis

Chunping Liu, Qiuyang Zhao, Zhi Li, Shuntao Wang, Yiquan Xiong, Zeming Liu and Tao Huang _

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Oncotarget. 2017; 8:86556-86565. https://doi.org/10.18632/oncotarget.21242

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Abstract

Chunping Liu1,*, Qiuyang Zhao1,*, Zhi Li1, Shuntao Wang1, Yiquan Xiong1, Zeming Liu1,* and Tao Huang1

1Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

*These authors have contributed equally to this work

Correspondence to:

Tao Huang, email: [email protected]

Zeming Liu, email: [email protected]

Keywords: mixed subtype thyroid carcinoma, prognosis, SEER, PSM

Received: August 06, 2017 Accepted: August 29, 2017 Published: September 23, 2017

ABSTRACT

The prognosis of patients with mixed subtype thyroid cancer (MSTC) is unclear. The present study compared the prognoses of MSTC, papillary thyroid cancer (PTC), and follicular thyroid cancer (FTC) to provide a new perspective regarding the treatment guidelines for these diseases. We evaluated data from patients with thyroid cancer who were included in the Surveillance, Epidemiology, and End Results database between 2004 and 2013. Patient mortality was evaluated using Cox proportional hazards regression analyses and Kaplan-Meier analyses with log-rank tests. The univariate Cox regression analysis showed that the cancer-specific survival rate for MSTC was lower than that for PTC and FTC. However, in the multivariate Cox regression analysis, the cancer-specific survival rate for MSTC was similar to that for PTC and FTC. Before matching influence factors, the cancer-specific survival rate for MSTC was lower than that for PTC and FTC. However, after propensity score matching for relevant factors, the cancer-specific survival rate for MSTC was also similar to that for PTC and FTC. Our result would be beneficial and provide a guideline for the understanding of MSTC.

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Mixed subtype thyroid cancer: A surveillance, epidemiology, and end results database analysis

Abstract