Protease-activated receptor-1 (PAR-1): a promising molecular target for cancer

Xuan Liu; Jiahui Yu; Shangjin Song; Xiaoqiang Yue; Qi Li

doi:10.18632/oncotarget.21015

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Protease-activated receptor-1 (PAR-1): a promising molecular target for cancer

Xuan Liu, Jiahui Yu, Shangjin Song, Xiaoqiang Yue and Qi Li _

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Oncotarget. 2017; 8:107334-107345. https://doi.org/10.18632/oncotarget.21015

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Abstract

Xuan Liu1,2,*, Jiahui Yu2,*, Shangjin Song2, Xiaoqiang Yue2 and Qi Li1

1Department of Medical Oncology and Cancer Institute, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

2Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

*These authors contributed equally to this work

Correspondence to:

Qi Li, email: [email protected]

Xiaoqiang Yue, email: [email protected]

Keywords: PAR-1, cancer, carcinogenesis, invasion, metastasis

Received: June 24, 2017 Accepted: August 27, 2017 Published: September 18, 2017

ABSTRACT

PAR-1 is expressed not only in epithelium, neurons, astrocytes, immune cells, but also in cancer-associated fibroblasts, ECs (epithelial cells), myocytes of blood vessels, mast cells, and macrophages in tumor microenvironment, whereas PAR-1 stimulates macrophages to synthesize and secrete thrombin as well as other growth factors, resulting in enhanced cell proliferation, tumor growth and metastasis. Therefore, considerable effort has been devoted to the development of inhibitors targeting PAR-1. Here, we provide a comprehensive review of PAR-1’s role in cancer invasiveness and dissemination, as well as potential therapeutic strategies targeting PAR-1 signaling.

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Protease-activated receptor-1 (PAR-1): a promising molecular target for cancer

Abstract