Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma

Qiwei Yang; Ye Wang; Xiuwu Pan; Jianqing Ye; Sishun Gan; Fajun Qu; Lu Chen; Chuanmin Chu; Yi Gao; Xingang Cui

doi:10.18632/oncotarget.20742

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma

Qiwei Yang, Ye Wang, Xiuwu Pan, Jianqing Ye, Sishun Gan, Fajun Qu, Lu Chen, Chuanmin Chu, Yi Gao and Xingang Cui _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:78989-79002. https://doi.org/10.18632/oncotarget.20742

Metrics: PDF 1486 views | HTML 2578 views | ?

Abstract

Qiwei Yang1,2,*, Ye Wang3,*, Xiuwu Pan1,2,*, Jianqing Ye1, Sishun Gan1, Fajun Qu1, Lu Chen4, Chuanmin Chu1, Yi Gao4 and Xingang Cui1

1Department of Urology, The Third Affiliated Hospital of Second Military Medical University (Eastern Hepatobiliary Surgery Hospital), Shanghai 201805, People’s Republic of China

2Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, People’s Republic of China

3Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200082, People’s Republic of China

4Department of Urology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Xingang Cui, email: [email protected]

Yi Gao, email: [email protected]

Chuanmin Chu, email: [email protected]

Keywords: renal cell carcinoma, Wnt/β-catenin, Frizzled 8, proliferation, metastasis

Received: October 31, 2016 Accepted: August 08, 2017 Published: September 08, 2017

ABSTRACT

Recent reports have shown a rapid rise in the incidence of renal cell carcinoma (RCC), and Wnt (Wingless-related integration site) signaling pathway is important in RCC. Frizzled 8 (FZD8) is a member of Frizzled (FZD) receptor family which could activate canonical or non-canonical Wnt/β-catenin pathways. Nevertheless, the role of FZD8 in RCC is poorly investigated. The immunohistochemical analysis showed high expression of FZD8 in RCC tissues compared with peri-tumor tissues. FZD8 knockdown decreased the ability of proliferation and metastasis of RCC cells. Research revealed that the FZD8 regulated the transcription of Cyclin D1, c-Myc, and could promote the epithelial to mesenchymal transition (EMT) by mediating Vimentin and Snail through the Wnt/β-catenin signaling pathway. In addition, the results of our experiment revealed that FZD8 is involved in the regulation of non-canonical Wnt signaling pathway. These data suggested that the expression of FZD8 may play an important role in the proliferation and metastasis of RCC, and serve as a putative promising drug target for human RCC therapy.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 20742

Publication Alerts

Research Papers:

Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma

Abstract