Prognostic value of lymphocyte-to-monocyte ratio among Asian lung cancer patients: a systematic review and meta-analysis
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Wen Li1,2,*, Guangzhi Ma2,3,*, Qiang Wu2,*, Yunfu Deng2, Ya Liu1 and Jing Wang1
1Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, P.R. China
2Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, P.R. China
3Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, P.R. China
*These authors contributed equally to this work
Jing Wang, email: email@example.com
Keywords: lymphocyte to monocyte ratio (LMR), lung cancer, prognosis, meta-analysis
Received: July 08, 2017 Accepted: August 04, 2017 Published: August 28, 2017
Purpose: Numerous studies have reported the prognostic significance of lymphocyte-to-monocyte ratio (LMR) in malignancies, but its prognostic value among lung cancer remains controversial. This meta-analysis aimed to explore the prognostic significance of LMR in lung cancer patients.
Results: Eight studies including 3954 patients were included in this meta-analysis. Pooled results indicated that low LMR was significantly associated with poorer progression-free survival (hazard ratio (HR): 1.431, 95% confidence interval (CI): 1.294–1.582, p < 0.001) and overall survival (OS) (HR: 1.651, 95% CI: 1.306–2.086, p < 0.001), compared with high LMR. Similar results were observed in subgroups regardless of treatment, LMR cut-off value, or districts. However, no significant correlation between the LMR and OS was observed in the small cell lung cancer (SCLC) subgroup (HR = 1.262, 95% CI: 0.864–1.841, p = 0.229).
Materials and Methods: Identified literatures were extracted and retrieved from PubMed, Embase, Web of Science, and the Cochrane Library databases; All eligible studies focused on the association between LMR and the prognosis of lung cancer.
Conclusions: Low LMR is associated with poor outcomes among lung cancer patients. Further studies are needed to discuss the correlation between LMR and lung cancer prognosis.
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