Prognostic value of c-Met overexpression in pancreatic adenocarcinoma: a meta-analysis

Jung Han Kim; Hyeong Su Kim; Bum Jun Kim; Jin Lee; Hyun Joo Jang

doi:10.18632/oncotarget.20392

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Meta-Analysis:

Prognostic value of c-Met overexpression in pancreatic adenocarcinoma: a meta-analysis

Jung Han Kim _, Hyeong Su Kim, Bum Jun Kim, Jin Lee and Hyun Joo Jang

PDF | HTML | How to cite

Oncotarget. 2017; 8:73098-73104. https://doi.org/10.18632/oncotarget.20392

Metrics: PDF 2002 views | HTML 1968 views | ?

Abstract

Jung Han Kim1, Hyeong Su Kim1, Bum Jun Kim1,2, Jin Lee3 and Hyun Joo Jang3

1Division of Hemato-Oncology, Department of Internal Medicine, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07441, Republic of Korea

2Department of Internal Medicine, National Army Capital Hospital, The Armed Forces Medical Command, Sungnam 13574, Republic of Korea

3Division of Gastroenterology, Department of Internal Medicine, Dongtan Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Hwasung 18450, Republic of Korea

Correspondence to:

Jung Han Kim, email: [email protected]

Hyun Joo Jang, email: [email protected]

Keywords: c-Met, pancreatic cancer, prognostic value, meta-analysis

Received: June 01, 2017 Accepted: August 07, 2017 Published: August 22, 2017

ABSTRACT

The overexpression of c-Met protein has been detected in pancreatic adenocarcinoma (PAC). However, its prognostic impact remains unclear. We performed this meta-analysis to evaluate the prognostic value of c-Met overexpression in PAC. A systematic computerized search of the electronic databases such as PubMed, Embase, and Google Scholar was carried out. From 5 studies, 423 patients who underwent surgical resection for PAC were included in the meta-analysis. Compared with patients with PAC showing low c-Met expression, patients with c-Met-high tumor had significantly worse disease-free survival (hazard ratio = 1.94 [95% confidence interval, 1.46–2.56], P = 0.00001) and overall survival (hazard ratio = 1.86 [95% confidence interval, 1.19–2.91], P = 0.006). In conclusion, this meta-analysis demonstrates that c-Met overexpression is a significant prognostic marker for poor survival in patients who underwent surgical resection for PAC.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 20392

Publication Alerts

Meta-Analysis:

Prognostic value of c-Met overexpression in pancreatic adenocarcinoma: a meta-analysis

Abstract