Do patients with oxyphilic cell papillary thyroid carcinoma have a poor prognosis? Analysis of the surveillance, epidemiology, and end results database 2004-2013 with propensity score matching

Chunping Liu; Qiuyang Zhao; Wen Zeng; Chen Chen; Jie Ming; Shuntao Wang; Yiquan Xiong; Chao Zhang; Tianwen Chen; Zeming Liu; Tao Huang

doi:10.18632/oncotarget.20355

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Research Papers:

Do patients with oxyphilic cell papillary thyroid carcinoma have a poor prognosis? Analysis of the surveillance, epidemiology, and end results database 2004-2013 with propensity score matching

Chunping Liu, Qiuyang Zhao, Wen Zeng, Chen Chen, Jie Ming, Shuntao Wang, Yiquan Xiong, Chao Zhang, Tianwen Chen, Zeming Liu and Tao Huang _

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Oncotarget. 2017; 8:77075-77085. https://doi.org/10.18632/oncotarget.20355

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Abstract

Chunping Liu1,*, Qiuyang Zhao1,*, Wen Zeng2, Chen Chen1, Jie Ming1, Shuntao Wang1, Yiquan Xiong1, Chao Zhang3, Tianwen Chen4, Zeming Liu1 and Tao Huang1

1Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

2Department of Ophthalmology, Zhongnan Hospital, Wuhan University, Wuhan, China

3Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

4Department of Breast and Thyroid Surgery, Affiliated Nanshan Hospital, Guangdong Medical University, Shenzhen, China

*These authors have contributed equally to this work

Correspondence to:

Tao Huang, email: [email protected]

Zeming Liu, email: [email protected]

Keywords: oxyphilic cell papillary thyroid carcinoma, prognosis, SEER, PSM

Received: June 11, 2017 Accepted: July 26, 2017 Published: August 18, 2017

ABSTRACT

The prognosis of oxyphilic cell papillary thyroid carcinoma (OCPTC) remains unclear. The aim of this study was to investigate the prognosis of OCPTC and provide a new perspective on treatment guidelines for these patients. We investigated a large cohort of DTC patients from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2013. Patient mortality was examined by Kaplan-Meier analyses with log-rank tests and Cox proportional hazards regression analyses. In the study cohort, the rate of cancer-specific mortality per 1000 person-years for OCPTC was lower than that for classic papillary thyroid cancer (CPTC) and follicular thyroid cancer (FTC). According to the multivariate Cox regression model, the cancer-specific and all-cause mortality rates of OCPTC were similar to that of CPTC and FTC. The cancer-specific survival rate in patients with OCPTC was higher than that in patients with FTC, but similar to patients with CPTC, after matching for influential factors using propensity score matching analysis. The unanticipated prognosis provided new implications for the treatment of patients with OCPTC.

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Research Papers:

Do patients with oxyphilic cell papillary thyroid carcinoma have a poor prognosis? Analysis of the surveillance, epidemiology, and end results database 2004-2013 with propensity score matching

Abstract