LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells

Yali Yang; Mingxin Ren; Chao Song; Dan Li; Shahid Hussain Soomro; Yajie Xiong; Hongfeng Zhang; Hui Fu

doi:10.18632/oncotarget.20340

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Research Papers:

LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells

Yali Yang, Mingxin Ren, Chao Song, Dan Li, Shahid Hussain Soomro, Yajie Xiong, Hongfeng Zhang and Hui Fu _

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Oncotarget. 2017; 8:84123-84139. https://doi.org/10.18632/oncotarget.20340

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Abstract

Yali Yang1,*, Mingxin Ren1,*, Chao Song1, Dan Li1, Shahid Hussain Soomro1, Yajie Xiong1, Hongfeng Zhang2 and Hui Fu1

1Department of Anatomy and Embryology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China

2Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China

*These authors have contributed equally to this work

Correspondence to:

Hui Fu, email: [email protected]

Hongfeng Zhang, email: [email protected]

Keywords: lncRNAs, LINC00461, glioma, proliferation, migration

Received: February 10, 2017 Accepted: July 25, 2017 Published: August 18, 2017

ABSTRACT

An increasing number of reports have revealed that long non-coding RNAs are important players in tumorigenesis. Here we showed that long non-coding RNA LINC00461 is highly expressed in glioma tissues compared to non-neoplastic brain tissues. The knockdown of LINC00461 suppressed cyclinD1/A/E expression which led to G0/G1 cell cycle arrest and inhibited cell proliferation in glioma cells. LINC00461 suppression also inhibited glioma cell migration and invasion. The function of LINC00461 in glioma cells is partially mediated by MAPK/ERK and PI3K/AKT signaling pathways as down-regulation of LINC00461 expression suppressed ERK1/2 and AKT activities. Moreover, LINC00461 knockdown decreased expression levels of microRNA miR-9 and flanking genes MEF2C and TMEM161B. Taken together, our results demonstrate that LINC00461 is important for glioma progression affecting cell proliferation, migration and invasion via MAPK/ERK, PI3K/AKT, and possibly other signaling pathways.

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Research Papers:

LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells

Abstract