IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population

Bin Yang; Yuanwei Xu; Xinle Liu; Zhuochun Huang; Lanlan Wang

doi:10.18632/oncotarget.20319

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Research Papers:

IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population

Bin Yang, Yuanwei Xu, Xinle Liu, Zhuochun Huang and Lanlan Wang _

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Oncotarget. 2017; 8:70310-70316. https://doi.org/10.18632/oncotarget.20319

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Abstract

Bin Yang1,*, Yuanwei Xu2,*, Xinle Liu1,*, Zhuochun Huang1 and Lanlan Wang1

1Department of Lab Medicine, West China Hospital, Sichuan University, 610041 Chengdu, China

2West China Medical School, Sichuan University, 610041 Chengdu, China

*These authors contributed equally to this work

Correspondence to:

Lanlan Wang, email: [email protected]

Keywords: interleukin-23R, interleukin-17A, ankylosing spondylitis, genetic polymorphisms, C-reactive protein

Received: February 09, 2017 Accepted: August 04, 2017 Published: August 18, 2017

ABSTRACT

The association between the IL-23R and IL-17A polymorphisms and ankylosing spondylitis (AS) in the Southwest Chinese Population is still unclear. The purpose of this study is to detect the association between IL-23R and IL-17A polymorphisms and AS. A case–control study consisting of 486 AS patients and 480 healthy controls was performed. We used the high-resolution melting methods (HRM) to genotype five selected single nucleotide polymorphisms (SNPs), rs6693831, rs7517847, rs1884444, rs10889677 in the IL-23R gene and rs2275913 in the IL-17A gene. Meanwhile, the laboratory indexes were recorded. In this study, patients with genotype CC (p = 8.574E-8) and allele C (p = 3.206E-31) on SNP rs6693831 (IL-23R) showed decreased risk of AS. The genotype TT (p = 4.551E-6) and allele T (p = 0.02) on SNP rs1884444 (IL-23R) showed significant lower risk of AS. Individuals carrying the allele A of rs2275913 showed higher morbidity of AS (p = 0.04). We first detected that rs6693831 and rs1884444 in IL-23R gene and rs2275913 in IL-17A gene have genetic association with AS.

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Research Papers:

IL-23R and IL-17A polymorphisms correlate with susceptibility of ankylosing spondylitis in a Southwest Chinese population

Abstract