The role of BRCA status on prognosis in patients with triple-negative breast cancer

Yuxin Xie; Qiheng Gou; Qianqian Wang; Xiaorong Zhong; Hong Zheng

doi:10.18632/oncotarget.19895

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

The role of BRCA status on prognosis in patients with triple-negative breast cancer

Yuxin Xie, Qiheng Gou, Qianqian Wang, Xiaorong Zhong and Hong Zheng _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:87151-87162. https://doi.org/10.18632/oncotarget.19895

Metrics: PDF 1833 views | HTML 3146 views | ?

Abstract

Yuxin Xie1,*, Qiheng Gou1,*, Qianqian Wang1,*, Xiaorong Zhong1 and Hong Zheng1

1Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China

*These authors have contributed equally to this work

Correspondence to:

Hong Zheng, email: [email protected]

Keywords: BRCA, triple-negative breast cancer, prognosis, meta-analysis

Received: October 05, 2016 Accepted: July 18, 2017 Published: August 03, 2017

ABSTRACT

Studies have showed that dysfunction in the breast cancer susceptibility gene (BRCA) is associated with triple-negative breast cancer (TNBC); however, its effect on patient survival remains controversial. We investigated the distribution of BRCA1/2 mutations in unselected Chinese patients with TNBC and explored their roles in prognosis. Then a systematic review and meta-analysis were performed to evaluate the prognostic role of BRCA dysfunction, including BRCA1/2 germline/somatic mutations, BRCA1 promoter methylation, and low BRCA1 protein expression in TNBC patients. Pooled hazard ratios with 95% confidence intervals were estimated to determine the association between BRCA dysfunction and survival. Our results showed a high frequency of BRCA1/2 mutations, especially germline BRCA1 variants, were associated with bilateral breast cancer. Although no correlations were found between BRCA1/2 mutations and recurrence-free survival (RFS) or overall survival (OS). In the meta-analysis, patients with BRCA1 promoter methylation showed poor OS. However, there was a favorable impact on disease free survival (DFS) for TNBC patients with BRCA1 promoter methylation when received adjuvant-chemotherapy. In conclusion, BRCA1/2 mutations were associated with bilateral breast cancer and BRCA1 promoter methylation may have a prognostic effect on TNBC.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 19895

Publication Alerts

Research Papers:

The role of BRCA status on prognosis in patients with triple-negative breast cancer

Abstract