Oncotarget

Meta-Analysis:

MUC1 overexpression predicts worse survival in patients with non-small cell lung cancer: evidence from an updated meta-analysis

Xing Huang, Qi Sun, Chen Chen, Yi Zhang, Xin Kang, Jing-Yuan Zhang, Da-Wei Ma, Lei Xia, Lin Xu, Xin-Yu Xu _ and Bin-Hui Ren

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Oncotarget. 2017; 8:90315-90326. https://doi.org/10.18632/oncotarget.19861

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Abstract

Xing Huang1,*, Qi Sun2,*, Chen Chen3,*, Yi Zhang1, Xin Kang4, Jing-Yuan Zhang1, Da-Wei Ma1, Lei Xia1, Lin Xu5, Xin-Yu Xu1 and Bin-Hui Ren5

1Department of Pathology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China

2Department of Cardiothoracic Surgery, Jinling Hospital, Southern Medical University, Nanjing, Jiangsu, China

3Department of Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China

4Department of General Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China

5Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China

*These authors contributed equally to this work

Correspondence to:

Xin-Yu Xu, email: redxxy@163.com

Bin-Hui Ren, email: robbisen@163.com

Keywords: mucin1, biomarker, NSCLC, prognosis, meta-analysis

Received: February 28, 2017     Accepted: July 18, 2017     Published: August 03, 2017

ABSTRACT

Background: Previous studies on the prognostic role of MUC1 expression in non-small cell lung cancer (NSCLC) remain controversial. We conducted a meta-analysis to appraise the clinicopathological and prognostic effect of MUC1 in NSCLC patients.

Materials and Methods: Searches of PubMed, EMBASE and CNKI (Chinese National Knowledge Infrastructure) were conducted and relevant studies were extracted. The pooled hazard ratio (HR) or odds ratio (OR) with 95% confidence intervals (CIs) were used to estimate effects. Heterogeneity among studies and publication bias were also evaluated.

Results: A total of 15 studies with 1,682 patients were included in this meta-analysis. The pooled HRs indicated that elevated MUC1 expression was associated with poorer overall survival (HR = 2.12, 95% CI: 1.47–3.05; P < 0.001) and progression-free survival (HR = 2.00, 95% CI: 1.53-2.62; P < 0.001) in patients with NSCLC. Significant associations were also found in patients treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) (HR = 3.16, 95% CI: 2.21–4.52, P < 0.001) and with a platinum-based regimen (HR = 4.35, 95% CI: 2.45–7.72, P < 0.001). Additionally, MUC1 overexpression was significantly associated with performance status (OR = 2.32, 95% CI: 1.13–4.73, P = 0.021).

Conclusions: MUC1 could be a valuable biomarker of the prognoses of NSCLC patients.


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