Oncotarget

Research Papers:

IL-33 blockade suppresses tumor growth of human lung cancer through direct and indirect pathways in a preclinical model

Kailing Wang, Shan Shan, Zongjun Yang, Xia Gu, Yuanyuan Wang, Chunhong Wang and Tao Ren _

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Oncotarget. 2017; 8:68571-68582. https://doi.org/10.18632/oncotarget.19786

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Abstract

Kailing Wang1,*, Shan Shan1,3,*, Zongjun Yang2, Xia Gu1, Yuanyuan Wang1, Chunhong Wang1 and Tao Ren1,3

1Department of Respiratory Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China

2Department of Clinical Laboratory, Qingdao Women & Children Hospital, Qingdao 266034, China

3Department of Respiratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

*These authors have contributed equally to this work

Correspondence to:

Tao Ren, email: rentaosh@126.com

Chunhong Wang, email: wangch910@126.com

Keywords: lung cancer, IL-33, tumor-associated macrophage, regulatory T cell

Abbreviations: NSCLC: non-small-cell lung cancer; TAM: tumor-associated macrophage; Treg: regulatory T cell

Received: February 18, 2017     Accepted: June 18, 2017     Published: August 02, 2017

ABSTRACT

Non-small-cell lung cancer (NSCLC) is the most common type in lung cancer, a leading cause of cancer-related death worldwide. Our previous study unraveled a pro-cancer function of IL-33 in fueling outgrowth and metastasis of human NSCLC cells. Herein, we determined that interfere with IL-33 activity was an effective strategy for limiting NSCLC tumor growth using a preclinical model with human NSCLC xenografts. IL-33 blockade efficiently inhibited tumor growth of NSCLC xenografts in immune-deficient mice. Mechanistically, IL-33 blockade suppressed outgrowth capacity of human NSCLC cells. Meanwhile, IL-33 blockade abrogated polarization of M2 tumor-associated macrophages (TAMs) and reduced accumulation of regulatory T cells (Tregs) in tumor microenvironments, shaping functional immune surveillance. In NSCLC patients, IL-33 expressions were positively correlated with Ki-67 proliferation index and expressions of M2 TAM- and Teg-related genes. These findings identify IL-33 as a dual-functional factor in NSCLC pathogenesis and suggest IL-33 blockade as a promising therapeutic for NSCLC patients.


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