Oncotarget

Research Papers:

Association between MPHOSPH6 gene polymorphisms and IgA nephropathy risk in a Chinese Han population

Xiaohong Yang, Yin Zhang, Wenning Li, Yan Su, Dan Niu, Yanni Wang, Haiyang Huang, Hui Han, Daofa Zhang, Maowei Xie, Huiluan Su, Wentan Xu and Jiali Wei _

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Oncotarget. 2017; 8:72375-72380. https://doi.org/10.18632/oncotarget.19758

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Abstract

Xiaohong Yang1,*, Yin Zhang1,*, Wenning Li1, Yan Su1, Dan Niu2, Yanni Wang1, Haiyang Huang3, Hui Han1, Daofa Zhang1, Maowei Xie1, Huiluan Su1, Wentan Xu1 and Jiali Wei1

1Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China

2Department of Nephrology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

3Central Laboratory, Hainan General Hospital, Haikou Hainan 570311, China

*These authors have contributed equally to this work

Correspondence to:

Jiali Wei, email: drjialiwei@163.com

Keywords: IgA nephropathy (IgAN), MPHOSPH6, single nucleotide polymorphisms (SNPs), association study

Received: May 10, 2017     Accepted: July 03, 2017     Published: August 01, 2017

ABSTRACT

Multiple genetic and environmental factors together contribute to the risk of IgA nephropathy (IgAN). MPHOSPH6 play an important role in the recruitment of the exosome to the pre-rRNA. However, to date, little information is found about the association between MPHOSPH6 polymorphisms and the IgAN risk. In this case-control study, we genotyped five single nucleotide polymorphisms (SNPs) in MPHOSPH6 gene in 416 IgAN cases and 495 controls using Sequenom Mass-ARRAY technology and evaluated their association with IgAN using the χ2 and genetic model analysis. In the allelic model analysis, we determined rs1056654 was associated with a 0.774-fold decrease in the risk of IgAN (95%CI= 0.630-0.952; p = 0.015). In the genetic model analysis, we found that the “C/C” genotype of rs1056675 was associated with an increased risk of IgAN based on the codominant model (OR =1.48; 95% CI=1.03-2.13; p=0.033) and recessive model (OR =1.52; 95% CI=1.11-2.09; p=0.0095). The “G/A-A/A” genotype of rs1056654 was associated with a decreased risk of IgAN based on the dominant model (OR =0.75; 95% CI=0.58-0.98; p=0.032) and log-additvie model (OR =0.78; 95% CI=0.64-0.96; p=0.0188). Our data suggested that gene polymorphisms in the MPHOSPH6 may exert influences IgAN susceptibility in a Chinese Han population.


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