Single nucleotide polymorphisms in  ZNF208  are associated with increased risk for HBV in Chinese people

Hengxin Li; Jun Chen; RuiZhi Zhang; Ran Xu; Zhe Zhang; Le Ren; Qi Yang; Yumei Tian; Daxu Li

doi:10.18632/oncotarget.19669

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Research Papers:

Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people

Hengxin Li, Jun Chen, RuiZhi Zhang, Ran Xu, Zhe Zhang, Le Ren, Qi Yang, Yumei Tian _ and Daxu Li

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Oncotarget. 2017; 8:112451-112459. https://doi.org/10.18632/oncotarget.19669

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Abstract

Hengxin Li1,*, Jun Chen2,*, RuiZhi Zhang3, Ran Xu4, Zhe Zhang4, Le Ren4, Qi Yang5,6, Yumei Tian7 and Daxu Li3

1Xi’an Center for Disease Control and Prevention, Xi’an, Shaanxi 710054, China

2Department of Pharmacy, The Ankang Central Hospital, Ankang, Shaanxi 725000, China

3Department of Stomatology, The Ankang Central Hospital, Ankang, Shaanxi 725000, China

4Department of Stomatology, The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

5Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China

6Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China

7Xi'an Mental Health Center, Xi’an, Shaanxi 710061, China

*These authors have contributed equally to this work

Correspondence to:

Yumei Tian, email: [email protected]

Daxu Li, email: [email protected]

Keywords: ZNF208; SNPs; HBV; susceptibility; Chinese Han population

Received: March 04, 2017 Accepted: May 22, 2017 Published: July 28, 2017

ABSTRACT

Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi’an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype A_rs2188972T_rs2188971A_rs8103163A_rs7248488 (OR = 1.42; 95% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV.

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Research Papers:

Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people

Abstract