Linc-ROR induces epithelial-to-mesenchymal transition in ovarian cancer by increasing Wnt/&#x03B2;-catenin signaling

Yanhui Lou; Huanhuan Jiang; Zhumei Cui; Lingzhi Wang; Xiangyu Wang; Tian Tian

doi:10.18632/oncotarget.19545

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Linc-ROR induces epithelial-to-mesenchymal transition in ovarian cancer by increasing Wnt/β-catenin signaling

Yanhui Lou _, Huanhuan Jiang, Zhumei Cui, Lingzhi Wang, Xiangyu Wang and Tian Tian

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:69983-69994. https://doi.org/10.18632/oncotarget.19545

Metrics: PDF 2089 views | HTML 2438 views | ?

Abstract

Yanhui Lou1, Huanhuan Jiang1, Zhumei Cui1, Lingzhi Wang1, Xiangyu Wang1 and Tian Tian1

1Department of Gynecology, Affiliated Hospital of Qingdao University, Qingdao 266100, China

Correspondence to:

Yanhui Lou, email: [email protected]

Keywords: ovarian cancer, long non-coding RNA, epithelial-to-mesenchymal transition, invasion, metastasis

Received: January 16, 2017 Accepted: June 29, 2017 Published: July 25, 2017

ABSTRACT

Long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) is an intergenic long non-coding RNA (lncRNA) previously shown to contribute to tumorigenesis in several malignancies. However, little is known about whether linc-ROR has a role in ovarian cancer progression. In this study, we found that linc-ROR expression was increased in high-grade ovarian serous cancer tissues compared with normal ovarian tissues or normal fallopian tube tissues. Furthermore, the level of linc-ROR expression was associated with ovarian cancer International Federation of Gynecology and Obstetrics stage and lymph node metastasis. Linc-ROR promoted ovarian cancer cell proliferation both in vitro and in vivo, and contributed to cell migration and invasion. Linc-ROR knockdown in ovarian cancer cell lines inhibited the epithelial-to-mesenchymal transition (EMT) program, which led to ovarian cancer cell metastasis through the repression of canonical Wnt/β-catenin signaling. Together, our results indicated that linc-ROR induces EMT in ovarian cancer cells and may be an important molecule in the invasion and metastasis of ovarian cancer.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 19545

Publication Alerts

Research Papers:

Linc-ROR induces epithelial-to-mesenchymal transition in ovarian cancer by increasing Wnt/β-catenin signaling

Abstract