Oncotarget

Research Papers:

Interferon-τ increases BoLA-I for implantation during early pregnancy in dairy cows

Zhe Zhu, Binbin Li, Yue Wu, Xiao Wang and GanZhen Deng _

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Oncotarget. 2017; 8:95095-95107. https://doi.org/10.18632/oncotarget.19282

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Abstract

Zhe Zhu1, Binbin Li1, Yue Wu1, Xiao Wang1 and GanZhen Deng1

1College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China

Correspondence to:

GanZhen Deng, email: gzdeng1963@sohu.com

Keywords: interferon-τ, dairy cow, BoLA-I, nidation, early pregnancy

Received: March 10, 2017     Accepted: June 09, 2017     Published: July 17, 2017

ABSTRACT

Interferon-τ (IFN-τ) signals pregnancy recognition in ruminants. We investigated the effects of IFN-τ produced by embryo trophoblastic cells (ETCs) on expression of bovine leukocyte antigen-I (BoLA-I), a bovine analogue of human MHC-I, in endometrial luminal epithelial cells (EECs) during early pregnancy in dairy cows. Expression of IFN-τ and BoLA-I was increased in endometrial tissues during early pregnancy. Expression of the anti-inflammatory cytokine IL-10 was increased in endometrial tissues, while expression of the pro-inflammatory cytokine IL-6 was decreased, indicating immunosuppression. Progesterone increased IFN-τ expression in EECs. IFN-τ increased p-STAT1 and p-STAT3 levels in EECs, but reduced TRAF3 levels. In addition, IFN-τ increased expression of BoLA-I and IL-10, but decreased expression of IL-6 in EECs. These results indicate that IFN-τ enables stable implantation in dairy cows by increasing expression of BoLA-I, and by immunosuppression mediated by increased IL-10 and decreased IL-6 expression.


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