Oncotarget

Research Papers:

A prospective appraisal of preoperative body mass index in D2-resected patients with non-metastatic gastric carcinoma and Siewert type II/III adenocarcinoma of esophagogastric junction: results from a large-scale cohort

Lei Huang, Zhi-Jian Wei, Tuan-Jie Li, Yu-Ming Jiang and A-Man Xu _

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Oncotarget. 2017; 8:68165-68179. https://doi.org/10.18632/oncotarget.19251

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Abstract

Lei Huang1, Zhi-Jian Wei1, Tuan-Jie Li2, Yu-Ming Jiang2 and A-Man Xu1,3

1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China

2Department of General Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, China

3Department of General Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China

Correspondence to:

A-Man Xu, email: amanxu@163.com

Lei Huang, email: huangleizhenting@126.com

Keywords: gastric cancer, adenocarcinoma of esophagogastric junction, body mass index, cancer-specific survival, prospective cohort study

Received: March 13, 2017    Accepted: June 16, 2017    Published: July 12, 2017

ABSTRACT

Objective: To prospectively investigate associations of presurgical body mass index (BMI) with clinicopathological factors and its prognostic significance in radically D2-resected patients with non-metastasized gastric cancer (GC) and Siewert type II/III adenocarcinoma of esophagogastric junction (AEG).

Methods: A large prospective cohort consisting of radically-resected GC and AEG patients was analyzed. Follow-up was successful in 671 out of 700 patients, who were categorized into underweight (BMI<18.5), normal-weight (BMI=18.5-22.9), overweight (BMI=23-24.9), and obese (BMI≥25) groups according to Asian standards. BMI-associated factors were explored using multivariable logistic regression with adjustment. Cancer-specific survival analyses were conducted applying both univariable and multivariable Cox regression methods.

Results: Pre-operation, higher hemoglobin levels and smaller anemia proportions were observed in larger BMI groups. Higher BMI tended to be associated with higher neutrophil-lymphocyte ratios (NLRs). Patients with higher BMI had smaller tumors and more often stage I tumors, but longer surgical time and postsurgical stay. In multivariable analyses, higher hemoglobin levels, upper tumor location, poorer differentiation, and higher NLR were significantly associated with higher BMI. Overall, survival analyses revealed no significant role of BMI. However, in further stratifications after adjustment, compared to patients with normal BMI, obese patients had better survival in women, but worse in those with AEG; underweight was associated with reduced mortality risk in tumors differentiated well to moderately; overweight patients had increased death hazard when having thrombocytopenia.

Conclusion: Overall, preoperative BMI had limited prognostic significance in operated GC patients. However, under specific conditions (e.g., female, AEG, good differentiation, and thrombocytopenia), BMI might indicate postoperative survival.


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