Oncotarget

Meta-Analysis:

Long non-coding RNA TUG1 as a potential prognostic biomarker in human cancers: a meta-analysis

Peng-Ju Ma, Qing-Kai Guan, Lei Meng, Nan Qin, Jia Zhao and Bao-Zhe Jin _

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Oncotarget. 2017; 8:62454-62462. https://doi.org/10.18632/oncotarget.19099

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Abstract

Peng-Ju Ma1,*, Qing-Kai Guan1,*, Lei Meng1, Nan Qin1, Jia Zhao1 and Bao-Zhe Jin1

1Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, Henan Province, People’s Republic of China

*These authors have contributed equally to the work

Correspondence to:

Bao-Zhe Jin, email: jinbaozhe2016@163.com

Keywords: TUG1, neoplasms, prognosis, metastasis, meta-analysis

Received: March 29, 2017    Accepted: May 29, 2017    Published: July 08, 2017

ABSTRACT

LncRNA taurine upregulated gene 1 (TUG1) is reportedly dysregulated in various cancers. We performed this meta-analysis to clarify the usefulness of TUG1 as a prognostic marker in malignant tumors. The PubMed, Medline, OVID, Cochrane Library, and Web of Science databases were searched from inception to Jan 11, 2017. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to explore the relationship between TUG1 expression and overall survival (OS). Odds ratios (ORs) were calculated to assess the association between TUG1 expression and pathological parameters. Thirteen original studies covering 1,274 cancer patients were included in this meta-analysis. The pooled HR suggested that high TUG1 expression correlated with poor OS (pooled HR=1.41, 95% CI: 1.01-1.98) in cancer types other than non-small cell lung cancer. TUG1 expression was also related to distant metastasis (OR=3.24, 95% CI: 1.18-8.93), large tumor size (OR=4.07, 95% CI: 1.08-15.28) and advanced tumor stage (OR=3.45, 95% CI: 2.19-5.44). Begg’s funnel plot and Egger’s test showed no evidence of obvious asymmetry for overall survival or tumor stage. Thus high TUG1 expression appears predictive of poor OS, distant metastasis, advanced tumor stage and large tumor size. This suggests TUG1 expression could serve as a biomarker for poor prognosis in cancers.


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