Oncotarget

Case Reports:

Significant benefit of Nivolumab treating PD-L1 positive metastatic pulmonary carcinosarcoma: a case report and literature review

Zhe Zhang, Yishan Chen, Mingxia Ma, Junli Hao, Rui Ding, Lixin Han, Jiayun Zou, Lina Zhang, Qin Meng, Xiujuan Qu, Yunpeng Liu and Mingfang Zhao _

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Oncotarget. 2017; 8:96453-96459. https://doi.org/10.18632/oncotarget.19089

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Abstract

Zhe Zhang1, Yishan Chen1, Mingxia Ma1, Junli Hao1, Rui Ding1, Lixin Han1, Jiayun Zou1, Lina Zhang1, Qin Meng2, Xiujuan Qu1, Yunpeng Liu1 and Mingfang Zhao1

1 Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China

2 Suzhou Junmeng Bioscience Co., Ltd, Suzhou City, Jiangsu Province, China

Correspondence to

Mingfang Zhao, email:

Yunpeng Liu, email:

Keywords: pulmonary carcinosarcoma, programmed cell death protein-1 (PD-1), nivolumab, immunotherapy

Received: February 04, 2017 Accepted: May 22, 2017 Published: July 07, 2017

Abstract

Immunotherapy has recently become a new focus for the treatment of malignant tumors following the surgery, chemotherapy, radiotherapy, and molecular targeted therapy. Nivolumab, a human monoclonal antibody, is the first programmed cell death protein-1 (PD-1) inhibitor, which can prohibit the interaction of its ligand (PD-L1), restoring the immune response of T cells, and enhancing the recognition of tumor cells by the immune system. Pulmonary carcinosarcoma is an uncommon but highly aggressive tumor type with a poor prognosis. We described a case of pulmonary carcinosarcoma, with the positive expression of PD-L1, obtained a significant benefit from Nivolumab treatment in a 64-year-old Chinese man, which give us a clue that patients with pulmonary carcinosarcoma may benefit fromanti-PD-1 immunotherapy.


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PII: 19089