miRNA and lncRNA as biomarkers in cholangiocarcinoma(CCA)

Bo Zheng; Seogsong Jeong; Yanjing Zhu; Lei Chen; Qiang Xia

doi:10.18632/oncotarget.19044

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Reviews:

miRNA and lncRNA as biomarkers in cholangiocarcinoma(CCA)

Bo Zheng, Seogsong Jeong, Yanjing Zhu, Lei Chen _ and Qiang Xia

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Oncotarget. 2017; 8:100819-100830. https://doi.org/10.18632/oncotarget.19044

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Abstract

Bo Zheng1,2,*, Seogsong Jeong3,*, Yanjing Zhu1,2,*, Lei Chen1,2 and Qiang Xia3

1International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, P.R. China

2National Center for Liver Cancer, Shanghai 201805, P.R. China

3Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China

*These authors contributed equally to this work

Correspondence to:

Lei Chen, email: [email protected]

Qiang Xia, email: [email protected]

Keywords: miRNA, lncRNA, biomarker, cholangiocarcinoma, prediction

Received: May 09, 2017 Accepted: June 19, 2017 Published: July 06, 2017

ABSTRACT

The microRNAs are a group of 20 nucleotides-long non-coding RNAs. By binding to the 3’UTR region of target mRNA, microRNAs can perform extensive actions mediating gene expression at post-trancriptional stages. It makes microRNAs serve as very crucial regulators in various biological progress including carcinogenesis. Long non-coding RNAs, however, are a subgroup of RNA with the length of 200 nucleotides. Unlike microRNAs, long non-coding RNAs can form secondary of tertiary domain based on their length. With the ability of directly interacting with DNA, RNA, protein, long non-coding RNAs have promoting or inhibitive functions in gene expression regulation. Furthermore, the abnormal expression of certain long non-coding RNAs has roused people’s interest in the role of long non-coding RNAs in tumorigenesis. Although the connection between microRNA/long non-coding RNA and CCA has been a hot field to researchers, the link between molecular mechanism and clinical outcome has been barely built. This review takes a retrospect at the latest researches on the link between microRNA/long non-coding RNA and cholangiocarcinoma and the potential of microRNA/long non-coding RNA serving as distinctive biomarkers for CCA in clinical practice.

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Reviews:

miRNA and lncRNA as biomarkers in cholangiocarcinoma(CCA)

Abstract