Oncotarget

Research Papers:

This article has been corrected. Correction in: Oncotarget. 2018; 9:36542.

Se2Mo10V3, a heteropoly compound containing selenium, inhibits tumor growth

Hong-Ning Zhang, Wei-Li Feng, Chun-Na An _ and Wen-Guang Li

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Oncotarget. 2017; 8:67871-67877. https://doi.org/10.18632/oncotarget.18909

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Abstract

Hong-Ning Zhang1, Wei-Li Feng2, Chun-Na An3 and Wen-Guang Li4

1Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

2Department of Pharmacology, School of Basic Medical Sciences, Qinghai University, Xining 810001, China

3Department of Pharmacology, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063009, China

4Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

Correspondence to:

Chun-Na An, email: ancna@126.com

Wen-Guang Li, email: zhangxz2012@yeah.net

Keywords: heteropoly compound containing selenium, Se2Mo10V3, anti-tumor, apoptosis, NF-κB/IκBα

Received: March 21, 2017     Accepted: May 30, 2017     Published: July 01, 2017

ABSTRACT

Selenium compounds have strong anti-tumor effects and are well-tolerated. We examined the anti-tumor effects of (NH4)2H15Se2VIMo10V3O52·2H2O (Se2Mo10V3), a heteropoly compound containing selenium. Se2Mo10V3 inhibited proliferation in K562 cells with a half-maximal inhibitory concentration of 78.72±2.82 mg/L after 48 h and 24.94±0.88 mg/L after 72 h. Typical apoptotic morphologies were also observed in K562 cells treated with Se2Mo10V3, as were increased intracellular levels of Ca2+, Mg2+, H+, and reactive oxygen species, and decreased mitochondrial membrane potential. In addition, Se2Mo10V3 treatment triggered cytochrome C release and inhibited IκBα degradation and NF-κB translocation. In vivo experiments revealed that 5 or 10 mg/kg Se2Mo10V3 inhibited the growth of sarcoma 180 and hepatoma 22 xenograft tumors. These results indicate that Se2Mo10V3 inhibits tumor growth both in vitro and in vivo and induces apoptosis in K562 cells, possibly by inhibiting the NF-κB/IκBα pathway.


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