Oncotarget

Research Papers:

MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A

Daozhang Yuan _, Shunsheng Zheng, Liyan Wang, Jing Li, Jianan Yang, Bin Wang, Xiong Chen and Xiaobo Zhang

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Oncotarget. 2017; 8:67663-67669. https://doi.org/10.18632/oncotarget.18801

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Abstract

Daozhang Yuan1, Shunsheng Zheng1, Liyan Wang1, Jing Li1, Jianan Yang1, Bin Wang1, Xiong Chen2 and Xiaobo Zhang2

1Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, People’s Republic of China

2Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, People’s Republic of China

Correspondence to:

Daozhang Yuan, email: daozhangyuan@163.com

Xiaobo Zhang, email: zhangxiaobo3537@163.com

Keywords: microRNA, miR-200c, LDHA, bladder cancer, proliferation

Received: November 09, 2016     Accepted: June 02, 2017     Published: June 28, 2017

ABSTRACT

Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c directly targets LDHA in bladder cancer cells. Ectopic expression of miR-200c inhibited LDHA-induced glycolysis, cell proliferation, and invasion. Thus, targeting LDHA through miR-200c is a potential therapeutic strategy in bladder cancer.


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