MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling

Yan Du; Juan Li; Tao Xu; Dan-Dan Zhou; Lei Zhang; Xiao Wang

doi:10.18632/oncotarget.18604

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Research Papers:

MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling

Yan Du, Juan Li, Tao Xu, Dan-Dan Zhou, Lei Zhang _ and Xiao Wang

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Oncotarget. 2017; 8:61510-61527. https://doi.org/10.18632/oncotarget.18604

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Abstract

Yan Du1,2, Juan Li3, Tao Xu1,2, Dan-Dan Zhou1,2, Lei Zhang1,2 and Xiao Wang4

1School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei 230032, China

2Institute for Liver Disease of Anhui Medical University, Anhui Medical University, Hefei 230032, China

3Anhui Provincial Hospital, Hefei 230032, China

4Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

Correspondence to:

Lei Zhang, email: [email protected]

Xiao Wang, email: [email protected]

Keywords: malignant gliomas, BNIP3, miR-145, apoptosis, notch signaling

Received: February 03, 2017 Accepted: May 22, 2017 Published: June 22, 2017

ABSTRACT

MicroRNAs (miRNAs) are involved in the pathogenesis of various human cancers. Here we show that miR-145 expression is decreased in human glioma samples, rat glioma tissues, and glioma cell lines, while expression of BNIP3 is increased. Over-expression of miR-145 or suppression of BNIP3 induced glioma cell apoptosis. BNIP3 is localized in the nucleus in glioma cells, and miR-145 inhibits BNIP3 expression by binding to the 3’ untranslated region of its mRNA. Interestingly, miR-145 and BNIP3 regulate glioma cell apoptosis by modulating Notch signaling. These results indicate that miR-145 increases glioma cell apoptosis by inhibiting BNIP3 and Notch signaling, and suggest that miR-145 may serve as a novel therapeutic target for malignant glioma.

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Research Papers:

MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling

Abstract