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Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma

Wenzhi Guo _, Jiakai Zhang, Dongyu Zhang, Shengli Cao, Gongquan Li, Shuijun Zhang, Zhihui Wang, Peihao Wen, Han Yang, Xiaoyi Shi, Jie Pan and Hua Ye

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Oncotarget. 2017; 8:48169-48177. https://doi.org/10.18632/oncotarget.18327

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Abstract

Wenzhi Guo1, Jiakai Zhang1, Dongyu Zhang2, Shengli Cao1, Gongquan Li1, Shuijun Zhang1, Zhihui Wang1, Peihao Wen1, Han Yang1, Xiaoyi Shi1, Jie Pan1 and Hua Ye3

1Department of Hepatic and Biliary Pancreatic Surgery, Henan Key Laboratory of Digestive Organ Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China

2Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China

3College of Public Health, Zhengzhou University, Zhengzhou, Henan, P.R. China

Correspondence to:

Wenzhi Guo, email: guoweizhi@aliyun.com

Hua Ye, email: yehuazz@aliyun.com

Keywords: circ-ITCH, hepatocellular carcinoma, susceptibility, survival

Received: March 20, 2017     Accepted: May 01, 2017     Published: June 01, 2017

ABSTRACT

Hepatocellular carcinoma (HCC) ranks the sixth most common cancer and the third cause of cancer-related mortality worldwide. Recent studies identified that circ-ITCH Suppresses mutiple cancers proliferation via inhibiting the Wnt/beta-Catenin pathway. In current study, conducted a genetic association study together with epidemiological follow-up study to delineate the role of circ-ITCH in the development and progression of HCC. we found rs10485505 (adjusted OR =1.18; 95% CI=1.06-1.31; P value =3.1×10-3) and rs4911154 (adjusted OR =1.27; 95% CI=1.14-1.43; P value =3.7×10-5) were significantly associated with increased HCC risk. The expression level of circ-ITCH was significantly lower in HCC tissues, compared with that in adjacent tissues (P value < 0.001). Cox regression analysis indicated that high expression of circ-ITCH was associated with favorable survival of HCC (HR=0.45; 95% CI=0.29-0.68; P value < 0.001). These results indicate that circ-ITCH may have an inhibitory effect on HCC, and could serve as susceptibility and prognostic biomarkers for HCC patients.


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