LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma

Jiangfeng Hu; Chenlin Song; Bensong Duan; Xiaoyan Zhang; Dongliang Li; Liang Zhu; Hengjun Gao

doi:10.18632/oncotarget.18279

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

This article has been corrected. Correction in: Oncotarget. 2018; 9:31311.

LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma

Jiangfeng Hu, Chenlin Song, Bensong Duan, Xiaoyan Zhang, Dongliang Li, Liang Zhu and Hengjun Gao _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:97835-97850. https://doi.org/10.18632/oncotarget.18279

Metrics: PDF 2049 views | HTML 4027 views | ?

Abstract

Jiangfeng Hu1,*, Chenlin Song2,*, Bensong Duan1,*, Xiaoyan Zhang3, Dongliang Li4, Liang Zhu5 and Hengjun Gao6,7

1Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China

2Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany

3Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai, Shanghai, China

4Department of Hepatobiliary Medicine, Fuzhou General Hospital of Nanjing Command, PLA, Fuzhou, China

5Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China

6National Engineering Center for Biochip at Shanghai, Shanghai, China

7Department of Gastroenterology, Institute of Digestive Diseases, Tongji University School of Medicine, Shanghai, China

*These authors contributed equally to this work

Correspondence to:

Hengjun Gao, email: [email protected]

Dongliang Li, email: [email protected]

Liang Zhu, email: [email protected]

Keywords: lncRNA-SVUGP2, hepatocellular carcinoma, proliferation, invasion, liver

Received: March 06, 2017 Accepted: April 25, 2017 Published: May 29, 2017

ABSTRACT

Numerous studies indicate that long noncoding RNAs (lncRNAs) are dysregulated in hepatocellular carcinoma (HCC) and might serve as potential diagnostic biomarkers and therapeutic targets of HCC. Therefore, it is interesting to globally identify the lncRNAs altered in HCC. In our study, we used microarray to profile the levels of lncRNAs and mRNAs in three pairs of HCC and their adjacent noncancerous samples. We found lncRNA-SVUGP2, which is a splice variant of the UGP2 gene, was down-regulated in HCC samples and correlates with a better prognosis in patients with HCC. Overexpression of lncRNA-SVUGP2 in HepG2 and Hep3B liver cancer cells suppresses cell proliferation in vitro and tumor growth in vivo. Moreover, lncRNA-SVUGP2 suppresses the invasion ability of liver cancer cell lines and downregulates the mRNA and protein levels of MMP2 and 9. Additionally, lncRNA-SVUGP2 positively or negatively correlates with many mRNAs in liver cancer tissues, indicating it is multifunctional in regulating carcinogenesis.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 18279

Publication Alerts

Research Papers:

LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma

Abstract